Vascular endothelial growth factor (VEGF) enhances gastric carcinoma invasiveness via integrin alpha(v)beta6

被引：45

作者：

Zhao, Rui ^{[1
]}

Liu, Xiang-qun ^{[2
]}

Wu, Xiao-peng ^{[1
]}

Liu, Yan-feng ^{[1
]}

Zhang, Zhao-yang ^{[1
]}

Yang, Guang-yun ^{[3
]}

Guo, Sen ^{[1
]}

Niu, Jun ^{[1
]}

Wang, Jia-yong ^{[1
]}

Xu, Ke-sen ^{[1
]}

机构：

[1] Shandong Univ, Qilu Hosp, Dept Hepatobiliary Surg, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Qilu Hosp, Dept Hlth Care, Jinan 250012, Shandong, Peoples R China

[3] Gen Hosp PLA, Dept Hepatobiliary Surg, Beijing 100853, Peoples R China

来源：

CANCER LETTERS | 2010年 / 287卷 / 02期

关键词：

VEGF; Integrin alpha v beta 6; Gastric carcinoma; Metastasis; COLON-CANCER CELLS; MATRIX DEGRADATION; EXPRESSION; KINASE; MAPK; MIGRATION; SUBUNIT; RNA;

D O I：

10.1016/j.canlet.2009.06.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Integrins play an important role in tumor metastasis induced by vascular endothelial growth factor (VEGF). However, in the case of gastric cancer, the precise role of VEGF in regulating integrin alpha v beta 6 is unclear. In this study, we found that most of the alpha v beta 6 integrin-positive gastric cancer tissues were also VEGF-positive. Furthermore, when gastric carcinoma cells were exposed to VEGF, expression of alpha v beta 6 integrin was up-regulated and the extracellular signal-related kinase (ERK) pathway was activated. When integrin alpha v beta 6 was blocked either with beta 6 siRNA or anti-alpha v beta 6 antibody, the migration of tumor cells normally induced by VEGF, as well as the activation of ERK, were markedly inhibited. Blocking the ERK signaling pathway significantly inhibited cell mobility. Taken together, the data suggest that VEGF is critical to the invasive process in human gastric cancer and that this occurs via up-regulation of integrin alpha v beta 6 expression and activation of ERK. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：150 / 156

页数：7

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