Regioselective and Stereoselective Difluoromethylation of Enamides with Difluoromethyltriphenylphosphonium Bromide via Photoredox Catalysis

被引：72
作者：
Zhu, Tong-Hao [1 ,3 ]
Zhang, Ze-Yu [1 ]
Tao, Ji-Yu [1 ]
Zhao, Kai [1 ]
Loh, Teck-Peng [1 ,2 ]
机构：
[1] Nanjing Tech Univ, Jiangsu Natl Synerget Innovat Ctr Adv Mat, Inst Adv Synth Sch Chem & Mol Engn, Nanjing 211816, Jiangsu, Peoples R China
[2] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore
[3] Taizhou Univ, Inst Adv Studies, 1139 Shifu Ave, Taizhou 318000, Peoples R China
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 15期
基金：
中国国家自然科学基金;
关键词：
LIGHT-INDUCED HYDRODIFLUOROMETHYLATION; COPPER-MEDIATED DIFLUOROMETHYLATION; ARYL BORONIC ACIDS; C-H ALKYNYLATION; ARYLBORONIC ACIDS; CYCLIC ENAMIDES; METAL-FREE; ALKENES; TRIFLUOROMETHYLATION; EFFICIENT;
D O I：
10.1021/acs.orglett.9b02361
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A regioselective and stereoselective difluoromethylation of enamides with bench-stable and easily accessible difluoromethyltriphenylphosphonium bromide is described. A broad array of synthetically important and geometrically defined beta-difluoromethylated enamides bearing various functional groups are obtained with up to 91% yield.
引用
收藏
页码：6155 / 6159
页数：5
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