Although white matter hyperintensities evolve in the course of ageing, few solutions exist to consider the lesion segmentation problem longitudinally. Based on an existing automatic lesion segmentation algorithm, a longitudinal extension is proposed. For evaluation purposes, a longitudinal lesion simulator is created allowing for the comparison between the longitudinal and the cross-sectional version in various situations of lesion load progression. Finally, applied to clinical data, the proposed framework demonstrates an increased robustness compared to available cross-sectional methods and findings are aligned with previously reported clinical patterns. (C) 2017 The Author(s). Published by Elsevier B.V.
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Hosp Salpetriere, INSERM, Unit Neuroepidemiol 708, F-75651 Paris 13, France
Univ Paris 06, Paris, FranceHosp Salpetriere, INSERM, Unit Neuroepidemiol 708, F-75651 Paris 13, France
Godin, Ophelia
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Tzourio, Christophe
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Univ Paris 06, Paris, FranceHosp Salpetriere, INSERM, Unit Neuroepidemiol 708, F-75651 Paris 13, France
Tzourio, Christophe
;
Maillard, Pauline
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Ctr Imaging Neurosci & Applicat Pathol, CNRS, CEA, UMR6232, Caen, France
Univ Caen Basse Normande, Caen, FranceHosp Salpetriere, INSERM, Unit Neuroepidemiol 708, F-75651 Paris 13, France
Maillard, Pauline
;
Alperovitch, Annick
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Univ Paris 06, Paris, FranceHosp Salpetriere, INSERM, Unit Neuroepidemiol 708, F-75651 Paris 13, France
Alperovitch, Annick
;
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Mazoyer, Bernard
;
Dufouil, Carole
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Univ Paris 06, Paris, FranceHosp Salpetriere, INSERM, Unit Neuroepidemiol 708, F-75651 Paris 13, France
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Univ Oxford, Nuffield Dept Clin Neurosci, Div Neurol, Stroke Prevent Res Unit, Oxford, EnglandUniv Oxford, Nuffield Dept Clin Neurosci, Div Neurol, Stroke Prevent Res Unit, Oxford, England
Grueter, Basil E.
;
Schulz, Ursula G.
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Univ Oxford, Nuffield Dept Clin Neurosci, Div Neurol, Stroke Prevent Res Unit, Oxford, EnglandUniv Oxford, Nuffield Dept Clin Neurosci, Div Neurol, Stroke Prevent Res Unit, Oxford, England
机构:
Hosp Salpetriere, INSERM, Unit Neuroepidemiol 708, F-75651 Paris 13, France
Univ Paris 06, Paris, FranceHosp Salpetriere, INSERM, Unit Neuroepidemiol 708, F-75651 Paris 13, France
Godin, Ophelia
;
Tzourio, Christophe
论文数: 0引用数: 0
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Univ Paris 06, Paris, FranceHosp Salpetriere, INSERM, Unit Neuroepidemiol 708, F-75651 Paris 13, France
Tzourio, Christophe
;
Maillard, Pauline
论文数: 0引用数: 0
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机构:
Ctr Imaging Neurosci & Applicat Pathol, CNRS, CEA, UMR6232, Caen, France
Univ Caen Basse Normande, Caen, FranceHosp Salpetriere, INSERM, Unit Neuroepidemiol 708, F-75651 Paris 13, France
Maillard, Pauline
;
Alperovitch, Annick
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, Paris, FranceHosp Salpetriere, INSERM, Unit Neuroepidemiol 708, F-75651 Paris 13, France
Alperovitch, Annick
;
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Mazoyer, Bernard
;
Dufouil, Carole
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Univ Paris 06, Paris, FranceHosp Salpetriere, INSERM, Unit Neuroepidemiol 708, F-75651 Paris 13, France
机构:
Univ Oxford, Nuffield Dept Clin Neurosci, Div Neurol, Stroke Prevent Res Unit, Oxford, EnglandUniv Oxford, Nuffield Dept Clin Neurosci, Div Neurol, Stroke Prevent Res Unit, Oxford, England
Grueter, Basil E.
;
Schulz, Ursula G.
论文数: 0引用数: 0
h-index: 0
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Univ Oxford, Nuffield Dept Clin Neurosci, Div Neurol, Stroke Prevent Res Unit, Oxford, EnglandUniv Oxford, Nuffield Dept Clin Neurosci, Div Neurol, Stroke Prevent Res Unit, Oxford, England