Total synthesis of phorboxazole A. 2. assembly of subunits and completion of the synthesis

被引：22

作者：

White, James D. ^{[1
]}

Lee, Tae Hee ^{[1
]}

Kuntiyong, Punlop ^{[1
]}

机构：

[1] Oregon State Univ, Dept Chem, Corvallis, OR 97331 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 26期

关键词：

D O I：

10.1021/ol062531j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Subunits of phorboxazole A containing C1-C2, C3-C8, C9-C19, C20-C32, C33-C41, and C42-C46 were connected in a sequence that first linked C32 with C33 and then C41 with C42. A C3-C8 fragment was joined to C9-C19, and the assembled unit was then joined with the left half of 1. Closure of the macrolide was accomplished by esterification of the C24 alcohol followed by intramolecular Horner-Wadsworth-Emmons condensation to set the (E)-C2-C3 alkene.

引用

页码：6043 / 6046

页数：4

共 19 条

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