TRANSFORMATIONS OF ETHYL 2-AMINO-4-(2-ETHOXY-2-OXOETHYL)THIAZOLE-5-CARBOXYLATE INTO 5-SUBSTITUTED 2-AMINO-4-OXO-4,5-DIHYDROTHIAZOLO [5,4-c] PYRIDINE-7-CARBOXYLATES

被引：3
|
作者：
Albreht, Alen [1 ]
Ursic, Uros [1 ]
Svete, Jurij [1 ]
Stanovnik, Branko [1 ]
机构：
[1] Univ Ljubljana, Dept Chem & Chem Technol, Ljubljana 1000, Slovenia
来源：
HETEROCYCLES | 2009年 / 78卷 / 09期
关键词：
Acetone-1,3-dicarboxylate; Enaminone; 2-Amino-5-arylamino and 2-Amino-5-aryl-4-oxo4,5dihydrothiazolo[5,4-c]pyridine-7-carboxylates; FACTOR XA INHIBITORS; ALKYL; 3-(DIMETHYLAMINO)PROPENOATES; THIAZOLO<5,4-C>PYRIDINES;
D O I：
10.3987/COM-09-11711
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ethyl 4-[1-(dimethylamino)-3-ethoxy-3-oxoprop-1-en-2-yl]-2-[(dimethylamino)methylideneamino]thiazole-5-carboxylate (2), prepared from ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)thiazole-5-carboxylate (1) according to a known procedure, was transformed with aromatic amines 3a-d into 5-aryl substituted 2-aminothiazolo[5,4-c]pyridine-7-carboxylates 5a-d, while treatment of 2 with monosubstituted hydrazines 6a-h produced 5-N-amino substituted thiazolo[5,4-c]pyridine-7-carboxylates 8a-h.
引用
收藏
页码：2343 / 2352
页数：10
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