Liver transplantation and hepatitis B virus infection: towards an immunoglobulin-free antiviral treatment after transplantation

被引：5
作者：
Chan, Albert C. Y. [1 ]
Fung, James Y. Y. [2 ]
Lo, Chung Mau [1 ]
机构：
[1] Univ Hong Kong, Dept Surg, Div Liver Transplantat, 102 Pok Fu Lam Rd, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China
来源：
CURRENT OPINION IN ORGAN TRANSPLANTATION | 2016年 / 21卷 / 02期
关键词：
entecavir; hepatitis B immune globulin; hepatitis B; immunoglobulin; liver transplantation; tenofovir; IMMUNE GLOBULIN; LAMIVUDINE PROPHYLAXIS; PASSIVE IMMUNOPROPHYLAXIS; ENTECAVIR MONOTHERAPY; DISOPROXIL FUMARATE; GRAFT REINFECTION; HBIG PROPHYLAXIS; SURFACE-ANTIGEN; CYCLOSPORINE-A; VACCINATION;
D O I：
10.1097/MOT.0000000000000293
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
Purpose of reviewThis article provides an update on the latest development on deploying oral nucleosides in an immunoglobulin-free regime against hepatitis B virus (HBV) recurrence after liver transplantation.Recent findingsEntecavir and tenofovir are the two newer oral nucleosides that are associated with a low virological rebound rate at less than 2% at 5 years. As a result, they have been applied as standalone treatment against HBV recurrence after liver transplantation without immunoglobulin. Recent evidence has shown that a hepatitis B surface antigen seroclearance rate of 86% and 91% after 1 and 2 years was achievable with entecavir monotherapy. Moreover, none of the patients had histological graft damage because of HBV recurrence and an overall survival over 80% at 7 years has been reported.SummaryWith newer and more potent oral nucleos(t)ide (NA) available, a hepatitis B immune globulin-free regimen after liver transplantation has become safe and feasible for suppression of HBV recurrence after liver transplantation, and for avoidance of HBV-related graft complications.
引用
收藏
页码：219 / 223
页数：5
相关论文
共 54 条
[1]   Identification and characterization of mutations in hepatitis B virus resistant to lamivudine [J].
Allen, MI ;
Deslauriers, M ;
Andrews, CW ;
Tipples, GA ;
Walters, KA ;
Tyrrell, DLJ ;
Brown, N ;
Condreay, LD .
HEPATOLOGY, 1998, 27 (06) :1670-1677
[2]   Failure of a reinforced triple course of hepatitis B vaccination in patients transplanted for HBV-related cirrhosis [J].
Angelico, M ;
Di Paolo, D ;
Trinito, MO ;
Petrolati, A ;
Araco, A ;
Zazza, S ;
Lionetti, R ;
Casciani, CU ;
Tisone, G .
HEPATOLOGY, 2002, 35 (01) :176-181
[3]   A Randomized Study of Adefovir Dipivoxil in Place of HBIG in Combination with Lamivudine As Post-Liver Transplantation Hepatitis B Prophylaxis [J].
Angus, Peter W. ;
Patterson, Scott J. ;
Strasser, Simone J. ;
McCaughan, Geoffrey W. ;
Gane, Edward .
HEPATOLOGY, 2008, 48 (05) :1460-1466
[4]   Combination low-dose hepatitis B immune globulin and lamivudine therapy provides effective prophylaxis against posttransplantation hepatitis B [J].
Angus, PW ;
McCaughan, GW ;
Gane, EJ ;
Crawford, DHG ;
Harley, H .
LIVER TRANSPLANTATION, 2000, 6 (04) :429-433
[5]   Vaccination against hepatitis B in liver transplant recipients:: Pilot analysis of cellular immune response shows evidence of HBsAg-specific regulatory T cells [J].
Bauer, Tania ;
Guenther, Matthias ;
Bienzle, Ulrich ;
Neuhaus, Ruth ;
Jilg, Wolfgang .
LIVER TRANSPLANTATION, 2007, 13 (03) :434-442
[6]   Successful hepatitis B vaccination in patients who underwent transplantation for hepatitis B virus-related cirrhosis:: Preliminary results [J].
Bienzle, U ;
Günther, M ;
Neuhaus, R ;
Neuhaus, P .
LIVER TRANSPLANTATION, 2002, 8 (06) :562-564
[7]   Immunization with an adjuvant hepatitis B vaccine after liver transplantation for hepatitis B-related disease [J].
Bienzle, U ;
Günther, M ;
Neuhaus, R ;
Vandepapeliere, P ;
Vollmar, J ;
Lun, A ;
Neuhaus, P .
HEPATOLOGY, 2003, 38 (04) :811-819
[8]   MODULATION OF THE IMMUNOLOGICAL RESPONSE TO HEPATITIS-B VIRUS BY ANTIBODIES [J].
CELIS, E ;
ABRAHAM, KG ;
MILLER, RW .
HEPATOLOGY, 1987, 7 (03) :563-568
[9]   Entecavir Treatment for up to 5 Years in Patients with Hepatitis B e Antigen-Positive Chronic Hepatitis B [J].
Chang, Ting-Tsung ;
Lai, Ching-Lung ;
Yoon, Seung Kew ;
Lee, Samuel S. ;
Coelho, Henrique Sergio M. ;
Carrilho, Flair Jose ;
Poordad, Fred ;
Halota, Waldemar ;
Horsmans, Yves ;
Tsai, Naoky ;
Zhang, Hui ;
Tenney, Daniel J. ;
Tamez, Ricardo ;
Iloeje, Uchenna .
HEPATOLOGY, 2010, 51 (02) :422-430
[10]   An Efficient Antiviral Strategy for Targeting Hepatitis B Virus Genome Using Transcription Activator-Like Effector Nucleases [J].
Chen, Jieliang ;
Zhang, Wen ;
Lin, Junyu ;
Wang, Fan ;
Wu, Min ;
Chen, Cuncun ;
Zheng, Ye ;
Peng, Xiuhua ;
Li, Jianhua ;
Yuan, Zhenghong .
MOLECULAR THERAPY, 2014, 22 (02) :303-311
123456