Membrane-encapsulated camouflaged nanomedicines in drug delivery

被引:29
作者
Ghosh, Suparna [1 ]
Girigoswami, Koyeli [1 ]
Girigoswami, Agnishwar [1 ]
机构
[1] CARE, CHRI, Fac Allied Hlth Sci, Med Bionanotechnol, Chennai 603103, Tamil Nadu, India
关键词
biological membrane; camouflaged; drug delivery; nanovectors; theranostics; STEM-CELL LINES; RED-BLOOD-CELLS; SIPULEUCEL-T; PROSTATE-CANCER; DENDRITIC CELLS; NEURAL PROGENITORS; PROMININ-1; CD133; GENE-THERAPY; EXOSOMES; NANOPARTICLES;
D O I
10.2217/nnm-2019-0155
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Owing to the limitations of conventional therapies, there has been an increasing need for nanomedicines for real-time diagnosis and effective treatment of life-threatening diseases. Despite the conceptual and technological success achieved by researchers worldwide, the complexities of biological systems, efficient engineering and formulation of monodispersed nanomedicines, inadequate information on bio-nano interactions, issues on health hazards, clinical trials and commercialization have set new challenges in biomedical research. This review highlights how the biological membrane improves the performance of nanomedicines in drug delivery. With the list of nanomedicines getting longer gradually to overcome the drawbacks of conventional therapeutics, it is important to concentrate on the interactions between nanostructures and living systems in order to improve the biocompatibility and therapeutic efficacy of functional nanomedicines.
引用
收藏
页码:2067 / 2082
页数:16
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