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Innate lymphoid cells: parallel checkpoints and coordinate interactions with T cells
被引:20
作者:
Huntington, Nicholas D.
[1
,2
,3
]
Carpentier, Sabrina
[4
]
Vivier, Eric
[5
,6
]
Belz, Gabrielle T.
[1
,2
,3
]
机构:
[1] Univ Melbourne, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia
[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3052, Australia
[3] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia
[4] MI MAbs, F-13288 Marseille, France
[5] Aix Marseille Univ, Ctr Immunol Marseille Luminy, INSERM, CNRS,UM2,U1104,UMR7280, F-13288 Marseille, France
[6] Hop Conception, Assistance Publ Hop Marseille, Immunol, F-13385 Marseille, France
基金:
英国医学研究理事会;
澳大利亚国家健康与医学研究理事会;
澳大利亚研究理事会;
欧洲研究理事会;
关键词:
TRANSCRIPTION FACTOR BCL11B;
NATURAL-KILLER-CELLS;
COMMENSAL BACTERIA;
IN-VIVO;
INTESTINAL INFLAMMATION;
CYTOKINE PRODUCTION;
TYPE-2;
IMMUNITY;
FACTOR GATA3;
STEM-CELLS;
HOMEOSTASIS;
D O I:
10.1016/j.coi.2015.11.008
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Protection of epithelial and mucosal surfaces is required for survival. The recent discovery of a diverse array of innate lymphoid cells that lie immediately beneath these surfaces has unexpectedly uncovered an entire defense system distinct from the adaptive system essential to protect these barriers. This multilayered design provides a robust system through coupling of two highly complementary networks to ensure immune protection. Here, we discuss the similarities in the hardwiring and diversification of innate lymphoid cells and T cells during mammalian immune responses.
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页码:86 / 93
页数:8
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