Targeting Mitochondria with Organelle-Specific Compounds: Strategies and Applications

被引:277
作者
Yousif, Lema F. [1 ]
Stewart, Kelly M. [1 ]
Kelley, Shana O. [1 ,2 ]
机构
[1] Univ Toronto, Fac Med, Dept Biochem, Toronto, ON M5S 3M2, Canada
[2] Univ Toronto, Dept Pharmaceut Sci, Leslie Dan Fac Pharm, Toronto, ON M5S 3M2, Canada
关键词
drug delivery; membranes; mitochondria; mitochondria-penetrating peptide; peptide transporters; CONTAINING MOLECULAR TRANSPORTERS; CELLULAR OXIDATIVE STRESS; PEPTIDE NUCLEIC-ACIDS; PROTEIN IMPORT; PLASMID DNA; RAT-LIVER; LIPOPHILIC CATION; OUTER-MEMBRANE; SIGNAL PEPTIDE; DRUG-DELIVERY;
D O I
10.1002/cbic.200900185
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mitochondria are the energy factories of the cell and also serve as a checkpoint regulating programmed cell death. Not surprisingly, dysfunctional mitochondria are implicated in a variety of diseases ranging from metabolic disorders to cancer. Treatment of these diseases through the delivery of targeted drugs, however, is impeded by the difficulty of penetrating the membranes that define this organelle. The properties of this barrier serve as a major obstacle to drug delivery and a lack of effective transporters has hindered the advancement of mitochondrial medicine. Recently, however, synthetic transporters that show promise for the mito-specific delivery of bioactive cargos have begun to emerge. This review summarizes the most exciting of these developments and discusses their applications.
引用
收藏
页码:1939 / 1950
页数:12
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