Microparticles and cardiovascular diseases

被引：48

作者：

Voukalis, Christos ^{[1
]}

Shantsila, Eduard ^{[1
]}

Lip, Gregory Y. H. ^{[2
,3
,4
]}

机构：

[1] Univ Birmingham, Inst Cardiovasc Sci, Birmingham, W Midlands, England

[2] Univ Liverpool, Liverpool Ctr Cardiovasc Sci, Liverpool, Merseyside, England

[3] Liverpool Heart & Chest Hosp, Liverpool, Merseyside, England

[4] Aalborg Univ, Aalborg Thrombosis Res Unit, Dept Clin Med, Aalborg, Denmark

来源：

ANNALS OF MEDICINE | 2019年 / 51卷 / 3-4期

关键词：

Microparticles; cardiovascular; inflammation; thrombosis; atherosclerosis; heart failure; PLATELET-DERIVED MICROPARTICLES; CIRCULATING ENDOTHELIAL MICROPARTICLES; TYPE-2; DIABETES-MELLITUS; HUMAN ATHEROSCLEROTIC PLAQUES; HEART-FAILURE PATIENTS; MYOCARDIAL-INFARCTION PATIENTS; SHED MEMBRANE MICROPARTICLES; MONOCYTE ACTIVATION MARKERS; TISSUE FACTOR ACTIVITY; ACUTE ISCHEMIC-STROKE;

D O I：

10.1080/07853890.2019.1609076

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Microparticles are a distinctive group of small vesicles, without nucleus, which are involved as significant modulators in several physiological and pathophysiological mechanisms. Plasma microparticles from various cellular lines have been subject of research. Data suggest that they are key players in development and manifestation of cardiovascular diseases and their presence, in high levels, is associated with chronic inflammation, endothelial damage and thrombosis. The strong correlation of microparticle levels with several outcomes in cardiovascular diseases has led to their utilization as biomarkers. Despite the limited clinical application at present, their significance emerges, mainly because their detection and enumeration methods are improving. This review article summarizes the evidence derived from research, related with the genesis and the function of microparticles in the presence of various cardiovascular risk factors and conditions. The current data provide a substrate for several theories of how microparticles influence various cellular mechanisms by transferring biological information.

引用

页码：193 / 223

页数：31

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