Obstructive sleep apnoea and dementia: is there a link?

被引:16
作者
Shastri, Abhishek [1 ]
Bangar, Santosh [2 ]
Holmes, John [2 ,3 ]
机构
[1] Dorset HealthCare Univ NHS Fdn Trust, Poole, Dorset, England
[2] Leeds & York Partnership NHS Fdn Trust, Leeds, W Yorkshire, England
[3] Univ Leeds, Sch Med, Leeds Inst Med Educ, Leeds LS2 9JT, W Yorkshire, England
关键词
sleep apnoea; dementia; cognition; MILD COGNITIVE IMPAIRMENT; ARMODAFINIL IMPROVES WAKEFULNESS; MAGNETIC-RESONANCE-SPECTROSCOPY; ALZHEIMERS-DISEASE; DAYTIME SLEEPINESS; CIRCADIAN-RHYTHM; RISK-FACTOR; MEMORY; DISORDERS; MELATONIN;
D O I
10.1002/gps.4345
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
ObjectiveObstructive sleep apnoea is a common sleep disturbance in people of all ages, while dementia is an increasing entity among the ageing population of the world. Recent studies have established a link between sleep apnoea and cognitive decline. This literature review explores this relationship and examines the mechanisms, neurobiology and treatment modalities. DesignThe study was conducted with the use of narrative literature overview. Results and conclusionsWhile there are numerous studies that establish a clear relationship between obstructive sleep apnoea, cognitive decline and dementia, more work is needed in understanding the mechanism and processes involved. A detailed understanding of pathophysiology of sleep and the relationship with cognitive decline will be vital in addressing the possibility of averting a likely reversible cause of dementia or cognitive decline. Copyright (c) 2015 John Wiley & Sons, Ltd.
引用
收藏
页码:404 / 409
页数:6
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