Cytotoxic sesquiterpenoids from Ligularia pleurocaulis

被引：13
作者：
Xie, Guang-Bo [1 ]
Xie, Ya [1 ]
Hu, Yang-Zhirong [1 ]
Zhu, Zhi-Xiang [2 ]
机构：
[1] Univ Elect Sci & Technol China, Sch Life Sci & Technol, 4,Sect 2,North Jianshe Rd, Chengdu 610054, Peoples R China
[2] Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
来源：
PHYTOCHEMISTRY | 2016年 / 125卷
基金：
中国国家自然科学基金;
关键词：
Ligularia pleurocaulis; Compositae; Sesquiterpenoid; Biligupleurolide; Cytotoxicity; Cu K alpha X-ray crystallography; EREMOPHILANE-TYPE SESQUITERPENOIDS; OCCURRING TERPENE DERIVATIVES; KANGTINGENSIS; RHIZOMES;
D O I：
10.1016/j.phytochem.2016.02.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The phytochemical investigation of whole plants of Ligularia pleurocaulis led to isolation of five sesquiter-penoids, including an eremophilenolide dimer named biligupleurolide, along with eight known sesquiterpenoids. Their structures were determined by spectroscopic methods including 2D NMR techniques, and the structures of biligupleurolide and ligupleurolide were confirmed by X-ray diffraction analysis. All of the isolated compounds were tested for their cytotoxic activity against three cancer cell lines (HepG2, A549 and MCF-7), and biligupleurolide showed moderate inhibitory activities, with IC50 values of 5.2, 5.6 and 8.4 mu M against MCF-7, HepG2 and A549, respectively. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：99 / 105
页数：7
相关论文
共 50 条
  • [41] Chemical and Cytotoxic Activity of three main Sesquiterpenoids from Warburgia ugandensis
    Kitte, Reni
    Tretbar, Maik
    Dluczek, Sarah
    Beckmann, Lorenz
    Marquardt, Peter
    Duenkel, Anna
    Schubert, Andreas
    Fricke, Stephan
    Tretbar, U. Sandy
    RESULTS IN CHEMISTRY, 2021, 3
  • [42] Sesquiterpenes from Ligularia intermedia
    Chen, HM
    Cai, MS
    Jia, ZJ
    PHYTOCHEMISTRY, 1997, 45 (07) : 1441 - 1444
  • [43] Cytotoxic Sesquiterpenoids and Diarylheptanoids from the Rhizomes of Curcuma elata Roxb.
    Chokchaisiri, Ratchanaporn
    Pimkaew, Prapapan
    Piyachaturawat, Pawinee
    Chalermglin, Rattana
    Suksamrarn, Apichart
    RECORDS OF NATURAL PRODUCTS, 2014, 8 (01) : 46 - 50
  • [44] Cytotoxic Sesquiterpenoids from Atractylodes chinensis (DC.) Koidz.
    Zhuang, Lei-Xin
    Liu, Yan
    Wang, Si-Yi
    Sun, Ye
    Pan, Juan
    Guan, Wei
    Hao, Zhi-Chao
    Kuang, Hai-Xue
    Yang, Bing-You
    CHEMISTRY & BIODIVERSITY, 2022, 19 (12)
  • [45] Two new cytotoxic sesquiterpenoids from Eupatorium lindleyanum DC.
    Huo, J
    Yang, SP
    Ding, J
    Yue, JM
    JOURNAL OF INTEGRATIVE PLANT BIOLOGY, 2006, 48 (04) : 473 - 477
  • [46] Germacrane-type sesquiterpenoids with cytotoxic activity from Sigesbeckia orientalis
    Liu, Na
    Wu, Cong
    Yu, Jin-hai
    Zhu, Kong-kai
    Song, Mei-na
    Yang, Feng-ying
    Feng, Run-liang
    Zhang, Yu-ying
    Chang, Wen-qiang
    Zhang, Hua
    BIOORGANIC CHEMISTRY, 2019, 92
  • [47] Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana
    Saito, Yoshinori
    Sasaki, Yoko
    Komiyama, Teppei
    Ohsaki, Ayumi
    Okamoto, Yasuko
    Gong, Xun
    Kuroda, Chiaki
    Tori, Motoo
    TETRAHEDRON, 2014, 70 (35) : 5878 - 5883
  • [48] Eremophilane Sesquiterpenes from the Genus Ligularia
    Wu, Ling
    Liao, Zhixin
    Liu, Chao
    Jia, Haiyang
    Sun, Jinyue
    CHEMISTRY & BIODIVERSITY, 2016, 13 (06) : 645 - 671
  • [49] Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast
    Hui-Yeng Yeannie Yap
    Mariano Jordi Muria-Gonzalez
    Boon-Hong Kong
    Keith A. Stubbs
    Chon-Seng Tan
    Szu-Ting Ng
    Nget-Hong Tan
    Peter S. Solomon
    Shin-Yee Fung
    Yit-Heng Chooi
    Microbial Cell Factories, 16
  • [50] Cytotoxic eremophilane sesquiterpenoids from the saprobic fungus Berkleasmium nigroapicale BCC 8220
    Isaka, Masahiko
    Srisanoh, Urarat
    Veeranondha, Sukitaya
    Choowong, Wilunda
    Lumyong, Saisamorn
    TETRAHEDRON, 2009, 65 (43) : 8808 - 8815
12345