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Cytotoxic sesquiterpenoids from Ligularia pleurocaulis
被引:13
作者:
Xie, Guang-Bo
[1
]
Xie, Ya
[1
]
Hu, Yang-Zhirong
[1
]
Zhu, Zhi-Xiang
[2
]
机构:
[1] Univ Elect Sci & Technol China, Sch Life Sci & Technol, 4,Sect 2,North Jianshe Rd, Chengdu 610054, Peoples R China
[2] Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
来源:
基金:
中国国家自然科学基金;
关键词:
Ligularia pleurocaulis;
Compositae;
Sesquiterpenoid;
Biligupleurolide;
Cytotoxicity;
Cu K alpha X-ray crystallography;
EREMOPHILANE-TYPE SESQUITERPENOIDS;
OCCURRING TERPENE DERIVATIVES;
KANGTINGENSIS;
RHIZOMES;
D O I:
10.1016/j.phytochem.2016.02.010
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The phytochemical investigation of whole plants of Ligularia pleurocaulis led to isolation of five sesquiter-penoids, including an eremophilenolide dimer named biligupleurolide, along with eight known sesquiterpenoids. Their structures were determined by spectroscopic methods including 2D NMR techniques, and the structures of biligupleurolide and ligupleurolide were confirmed by X-ray diffraction analysis. All of the isolated compounds were tested for their cytotoxic activity against three cancer cell lines (HepG2, A549 and MCF-7), and biligupleurolide showed moderate inhibitory activities, with IC50 values of 5.2, 5.6 and 8.4 mu M against MCF-7, HepG2 and A549, respectively. (C) 2016 Elsevier Ltd. All rights reserved.
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页码:99 / 105
页数:7
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