Driving proteins off DNA using applied tension

被引：88

作者：

Marko, JF ^{[1
]}

Siggia, ED ^{[1
]}

机构：

[1] CORNELL UNIV, ATOM & SOLID STATE PHYS LAB, ITHACA, NY 14853 USA

来源：

BIOPHYSICAL JOURNAL | 1997年 / 73卷 / 04期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0006-3495(97)78248-1

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Proteins that bind DNA so as to reduce its end-to-end length can be dissociated by application of force. The thermodynamics of this process are discussed, with special attention to the case of histones bound to DNA (i.e., a string of nucleosomes, or chromatin fiber). The histone octamer is predicted to be driven off chromatin fiber for tensions >2 piconewtons.

引用

页码：2173 / 2178

页数：6

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