The innovative potential of selenium- containing agents for fighting cancer and viral infections

被引：64

作者：

Ali, Wesam ^{[1
,2
]}

Benedetti, Rosaria ^{[3
]}

Handzlik, Jadwiga ^{[1
]}

Zwergel, Clemens ^{[2
,3
,4
]}

Battistelli, Cecilia ^{[5
]}

机构：

[1] Jagiellonian Univ, Med Coll, Fac Pharm, Dept Technol & Biotechnol Drugs, Med 9, PL-30688 Krakow, Poland

[2] Saarland Univ, Sch Pharm, Div Bioorgan Chem, Campus B 2-1, D-66123 Saarbrucken, Germany

[3] Luigi Vanvitelli Univ Campania, Dept Precis Med, Via L De Crecchio 7, I-80138 Naples, Italy

[4] Sapienza Univ Rome, Dept Drug Chem & Technol, Dept Excellence 2018 2022, Piazzale Aldo Moro 5, I-00185 Rome, Italy

[5] Sapienza Univ Rome, Fdn Cenci Bolognetti, Dept Mol Med, Ist Pasteur Italia,Dept Excellence 2018 2022, Viale Regina Elena 324, I-00161 Rome, Italy

来源：

DRUG DISCOVERY TODAY | 2021年 / 26卷 / 01期

关键词：

CARBONIC-ANHYDRASE IX; IN-VITRO; NUCLEIC-ACID; NANOPARTICLES; ANTICANCER; CELLS; INHIBITORS; IDENTIFICATION; DERIVATIVES; INFLUENZA;

D O I：

10.1016/j.drudis.2020.10.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Selenium-containing compounds have emerged as a potentially promising treatment for viral infections and tumor development and dissemination. Selenium per se is often considered as a toxic element with little or no beneficial effects, but considerable advances have been made in the understanding of the complex biology, chemistry and drug delivery of this element, especially when it is included in bioactive molecules. Here, we summarize and critically discuss recent findings in the field of selenium-based applications for the treatment of cancer and viral infections. Selenium-containing compounds have emerged as a potentially promising treatment for viral infections and tumor development and dissemination. Selenium per se is often considered as a toxic element with little or no beneficial effects, but considerable advances have been made in the understanding of the complex biology, chemistry and drug delivery of this element, especially when it is included in bioactive molecules. Here, we summarize and critically discuss recent findings in the field of selenium-based applications for the treatment of cancer and viral infections.

引用

页码：256 / 263

页数：8

共 64 条

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