Effects of anti-glaucoma medications on gangion cell survival: the DBA/2J mouse model

被引：86
作者：
Schuettauf, F
Quinto, K
Naskar, R
Zurakowski, D
机构：
[1] Univ Penn, Scheie Eye Inst, Dept Ophthalmol, Philadelphia, PA 19104 USA
[2] Harvard Univ, Sch Med, Childrens Hosp, Dept Orthopaed Surg, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Childrens Hosp, Dept Biostat, Boston, MA 02115 USA
来源：
VISION RESEARCH | 2002年 / 42卷 / 20期
关键词：
ocular hypertension; model; DBA/2J mouse; retinal ganglion cell survival;
D O I：
10.1016/S0042-6989(02)00188-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We studied whether several agents, approved or undergoing trials in human glaucoma, were effective in presenting ganglion cell loss in the DBA/2J mouse. Adult DBA/2J mice were treated with timolol, pilocarpine, brimonidine, dorzolamide, or NMDA-receptor antagonist memantine. Surviving retinal ganglion cells of treated and control mice were retrogradely labeled with fluorogold and counted after whole mount preparation. In treated mice, only memantine and timolol had significant effects on retinal ganglion cell survival (P < 0.0001 analysis of variance). Brimonidine was lethal to these mice, and these retinae were not analyzed Further. The DBA/2J mouse represents a promising candidate for further experimentation in ocular hypertension. (C) 2002 Elsevier Science Ltd. All rights reserved.
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收藏
页码：2333 / 2337
页数：5
相关论文
共 26 条
[1]   Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice [J].
Anderson, MG ;
Smith, RS ;
Hawes, NL ;
Zabaleta, A ;
Chang, B ;
Wiggs, JL ;
John, SWM .
NATURE GENETICS, 2002, 30 (01) :81-85
[2]   Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice [J].
Anderson, Michael G. ;
Smith, Richard S. ;
Savinova, Olga V. ;
Hawes, Norman L. ;
Chang, Bo ;
Zabaleta, Adriana ;
Wilpan, Robert ;
Heckenlively, John R. ;
Davisson, Muriel ;
John, Simon W. M. .
BMC GENETICS, 2001, 2 (1)
[3]  
Angelov O V, 1996, Eur J Ophthalmol, V6, P21
[4]  
Armitage P., 2001, STAT METHODS MED RES, V4th
[5]   Ophthalmic drops causing coma in an infant [J].
Berlin, RJ ;
Lee, UT ;
Samples, JR ;
Rich, LF ;
Tang-Liu, DDS ;
Sing, KA ;
Steiner, RD .
JOURNAL OF PEDIATRICS, 2001, 138 (03) :441-443
[6]   Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice [J].
Chang, B ;
Smith, RS ;
Hawes, NL ;
Anderson, MG ;
Zabaleta, A ;
Savinova, O ;
Roderick, TH ;
Heckenlively, JR ;
Davisson, MT ;
John, SWM .
NATURE GENETICS, 1999, 21 (04) :405-409
[7]   Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma [J].
Dreyer, EB ;
Zurakowski, D ;
Schumer, RA ;
Podos, SM ;
Lipton, SA .
ARCHIVES OF OPHTHALMOLOGY, 1996, 114 (03) :299-305
[8]   Safety and efficacy of brimonidine in children with glaucoma [J].
Enyedi, LB ;
Freedman, SF .
JOURNAL OF AAPOS, 2001, 5 (05) :281-284
[9]  
John SWM, 1997, INVEST OPHTH VIS SCI, V38, P249
[10]  
John SWM, 1998, INVEST OPHTH VIS SCI, V39, P951
123