Exposure to ambient air pollution and the incidence of lung cancer and breast cancer in the Ontario Population Health and Environment Cohort

被引:82
作者
Bai, Li [1 ]
Shin, Saeha [2 ]
Burnett, Richard T. [3 ]
Kwong, Jeffrey C. [1 ,2 ,4 ,5 ]
Hystad, Perry [6 ]
van Donkelaar, Aaron [7 ]
Goldberg, Mark S. [8 ,9 ]
Lavigne, Eric [10 ,11 ]
Weichenthal, Scott [12 ]
Martin, Randall, V [7 ,13 ]
Copes, Ray [2 ,4 ]
Kopp, Alexander [1 ]
Chen, Hong [1 ,2 ,3 ,4 ]
机构
[1] ICES, G177,2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
[2] Publ Hlth Ontario, Toronto, ON, Canada
[3] Hlth Canada, Environm Hlth Sci & Res Bur, Populat Studies Div, Ottawa, ON, Canada
[4] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada
[5] Univ Toronto, Dept Family & Community Med, Toronto, ON, Canada
[6] Oregon State Univ, Coll Publ Hlth & Human Studies, Corvallis, OR 97331 USA
[7] Dalhousie Univ, Dept Phys & Atmospher Sci, Halifax, NS, Canada
[8] McGill Univ, Dept Med, Montreal, PQ, Canada
[9] McGill Univ, Hlth Ctr, Res Inst, Ctr Outcomes Res & Evaluat, Montreal, PQ, Canada
[10] Hlth Canada, Air Hlth Sci Div, Ottawa, ON, Canada
[11] Univ Ottawa, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada
[12] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada
[13] Harvard Smithsonian Ctr Astrophys, Smithsonian Astrophys Observ, 60 Garden St, Cambridge, MA 02138 USA
基金
加拿大健康研究院;
关键词
incidence; lung cancer; breast cancer; ambient air pollution; LONG-TERM EXPOSURE; FINE PARTICULATE MATTER; CANADIAN CENSUS HEALTH; NITROGEN-DIOXIDE; NURSES HEALTH; FOLLOW-UP; RISK; ASSOCIATIONS; MORTALITY; TORONTO;
D O I
10.1002/ijc.32575
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Lung and female breast cancers are highly prevalent worldwide. Although the association between exposure to ambient fine particulate matter (PM2.5) and lung cancer has been recognized, there is less evidence for associations with other common air pollutants such as nitrogen dioxide (NO2) and ozone (O-3). Even less is known about potential associations between these pollutants and breast cancer. We conducted a population-based cohort study to investigate the associations of chronic exposure to PM2.5, NO2, O-3 and redox-weighted average of NO2 and O-3 (O-x) with incident lung and breast cancer, using the Ontario Population Health and Environment Cohort (ONPHEC), which includes all long-term residents aged 35-85 years who lived in Ontario, Canada, 2001-2015. Incident lung and breast cancers were ascertained using the Ontario Cancer Registry. Annual estimates of exposures were assigned to the residential postal codes of subjects for each year during follow-up. We used Cox proportional-hazards models adjusting for personal- and neighborhood-level covariates. Our cohorts for lung and breast cancer analyses included similar to 4.9 million individuals and similar to 2.5 million women, respectively. During follow-up, 100,146 incident cases of lung cancer and 91,146 incident cases of breast cancer were diagnosed. The fully adjusted analyses showed positive associations of lung cancer incidence with PM2.5 (hazard ratio [HR] = 1.02 [95% CI: 1.01-1.05] per 5.3 mu g/m(3)) and NO2 (HR = 1.05 [95% CI: 1.03-1.07] per 14 ppb). No associations with lung cancer were observed for O-3 or O-x. Relationships between PM2.5 and NO2 with lung cancer exhibited a sublinear shape. We did not find compelling evidence linking air pollution to breast cancer.
引用
收藏
页码:2450 / 2459
页数:10
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