B(C6F5)3-Catalyzed Cascade Reduction of Pyridines

被引：83
|
作者：
Liu, Zhi-Yun [1 ,2 ]
Wen, Zhi-Hui [1 ,2 ]
Wang, Xiao-Chen [1 ,2 ]
机构：
[1] Nankai Univ, State Key Lab, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Coll Chem, 94 Weijin Rd, Tianjin 300071, Peoples R China
[2] Nankai Univ, Inst Elementoorgan Chem, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Coll Chem, 94 Weijin Rd, Tianjin 300071, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 21期
基金：
中国国家自然科学基金;
关键词：
boron; chemoselectivity; homogeneous catalysis; nitrogen heterocycles; reduction; CATALYZED ASYMMETRIC HYDROGENATION; MULTIPLE STEREOGENIC CENTERS; SILYLATIVE REDUCTION; BOND ACTIVATION; HYDROSILYLATION; BORANE; MECHANISM; HYDROSILATION; HETEROCYCLES; DERIVATIVES;
D O I：
10.1002/anie.201702304
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
B(C6F5)(3) has been found to be an effective catalyst for reduction of pyridines and other electron-deficient N-heteroarenes with hydrosilanes (or hydroboranes) and amines as the reducing reagents. The success of this development hinges upon the realization of a cascade process of dearomative hydrosilylation (or hydroboration) and transfer hydrogenation. The broad functional-group tolerance (e.g. ketone, ester, unactivated olefins, nitro, nitrile, heterocycles, etc.) implies high practical utility.
引用
收藏
页码：5817 / 5820
页数：4
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