Role for protein-protein interaction databases in human genetics

被引:38
作者
Pattin, Kristine A. [1 ]
Moore, Jason H. [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
机构
[1] Dartmouth Hitchcock Med Ctr, Norris Cotton Canc Ctr, Lebanon, NH 03756 USA
[2] Dartmouth Med Sch, Computat Genet Lab, Dept Genet, Lebanon, NH USA
[3] Dartmouth Med Sch, Dept Community, Lebanon, NH USA
[4] Dartmouth Med Sch, Dept Family Med, Lebanon, NH USA
[5] Univ New Hampshire, Dept Comp Sci, Durham, NH 03824 USA
[6] Univ Vermont, Dept Comp Sci, Burlington, VT USA
[7] Translat Genom Res Inst, Phoenix, AZ USA
关键词
epistasis; expert knowledge; multifactor dimensionality reduction; protein-protein interaction; single nucleotide polymorphism; GENOME-WIDE ASSOCIATION; MULTIFACTOR-DIMENSIONALITY REDUCTION; INTERACTION NETWORK; CANDIDATE GENES; HUMAN-DISEASE; EPISTASIS; COMMON; SUSCEPTIBILITY; SEQUENCE; PATHWAYS;
D O I
10.1586/EPR.09.86
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Proteomics and the study of protein-protein interactions are becoming increasingly important in our effort to understand human diseases on a system-wide level. Thanks to the development and curation of protein-interaction databases, up-to-date information on these interaction networks is accessible and publicly available to the scientific community. As our knowledge of protein-protein interactions increases, it is important to give thought to the different ways that these resources can impact biomedical research. In this article, we highlight the importance of protein-protein interactions in human genetics and genetic epidemiology. Since protein-protein interactions demonstrate one of the strongest functional relationships between genes, combining genomic data with available proteomic data may provide us with a more in-depth understanding of common human diseases. In this review, we will discuss some of the fundamentals of protein interactions, the databases that are publicly available and how information from these databases can be used to facilitate genome-wide genetic studies.
引用
收藏
页码:647 / 659
页数:13
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