Pleiotropic Functions of H3K27Me3 Demethylases in Immune Cell Differentiation

被引：39
作者：
Bosselut, Remy [1 ]
机构：
[1] NCI, Lab Immune Cell Biol, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
来源：
TRENDS IN IMMUNOLOGY | 2016年 / 37卷 / 02期
关键词：
ACUTE LYMPHOBLASTIC-LEUKEMIA; HISTONE LYSINE DEMETHYLASES; REPRESSIVE COMPLEX 2; RNA-POLYMERASE-II; GENE-EXPRESSION; TARGET GENES; T-CELLS; MOLECULAR-MECHANISMS; H3; METHYLATION; LINEAGE FATE;
D O I：
10.1016/j.it.2015.12.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The trimethylation of histone H3 lysine 27 (H3K27Me3) contributes to gene repression, notably through recruitment of Polycomb complexes, and has long been considered essential to maintain cell identity. Whereas H3K27Me3 was thought to be stable and not catalytically reversible, the discovery of the Utx and Jmjd3 demethylases changed this notion, raising new questions on the role of these enzymes in gene expression and cell differentiation. Recent studies have demonstrated critical roles for Utx and Jmjd3 in the development and function of immune cells, and revealed both demethylase and demethylase-independent activities of these enzymes. I review these finding here, and discuss the current understanding of the mechanisms that underlie the broad, yet highly cell- and gene-specific, impact of these enzymes in vivo.
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页码：102 / 113
页数：12
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