Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm

被引:71
作者
Zhang, Jinghe [1 ,2 ,3 ,4 ]
Wu, Haibo [1 ,5 ]
Yao, XiaoHong [6 ]
Zhang, Dingyu [7 ]
Zhou, Yonggang [1 ,2 ,3 ,4 ]
Fu, Binqing [1 ,2 ,3 ,4 ]
Wang, Wei [1 ,5 ]
Li, Heng [1 ,5 ]
Wang, Zhe [1 ,5 ]
Hu, Ziming [1 ,2 ,3 ,4 ]
Ren, Yong [8 ]
Sun, Rui [1 ,2 ,3 ,4 ]
Tian, Zhigang [1 ,2 ,3 ,4 ]
Bian, Xiuwu [6 ]
Wei, Haiming [1 ,2 ,3 ,4 ]
机构
[1] Univ Sci & Technol China, Affiliated Hosp USTC 1, Div Life Sci & Med, Dept Pathol, Hefei, Anhui, Peoples R China
[2] Univ Sci & Technol China, Inst Immunol, Hefei, Anhui, Peoples R China
[3] Univ Sci & Technol China, Sch Life Sci, CAS Key Lab Innate Immun & Chron Dis, Hefei, Anhui, Peoples R China
[4] Univ Sci & Technol China, Med Ctr, Hefei, Anhui, Peoples R China
[5] Univ Sci & Technol China, Intelligent Pathol Inst, Div Life Sci & Med, Hefei, Anhui, Peoples R China
[6] Army Med Univ, Third Mil Med Univ, Southwest Hosp, Inst Pathol, Chongqing, Peoples R China
[7] Wuhan Hosp Infect Dis, Wuhan Jinyintan Hosp, Wuhan, Hubei, Peoples R China
[8] PLA, Gen Hosp Cent Theater Command, Wuhan, Peoples R China
关键词
D O I
10.1038/s41423-021-00665-0
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:1305 / 1307
页数:3
相关论文
共 9 条
[1]   Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study [J].
Cavalli, Giulio ;
De Luca, Giacomo ;
Campochiaro, Corrado ;
Della-Torre, Emanuel ;
Ripa, Marco ;
Canetti, Diana ;
Oltolini, Chiara ;
Castiglioni, Barbara ;
Din, Chiara Tassan ;
Boffini, Nicola ;
Tomelleri, Alessandro ;
Farina, Nicola ;
Ruggeri, Annalisa ;
Rovere-Querini, Patrizia ;
Di Lucca, Giuseppe ;
Martinenghi, Sabina ;
Scotti, Raffaella ;
Tresoldi, Moreno ;
Ciceri, Fabio ;
Landoni, Giovanni ;
Zangrillo, Alberto ;
Scarpellini, Paolo ;
Dagna, Lorenzo .
LANCET RHEUMATOLOGY, 2020, 2 (06) :E325-E331
[2]   Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome [J].
Chen, I-Yin ;
Moriyama, Miyu ;
Chang, Ming-Fu ;
Ichinohe, Takeshi .
FRONTIERS IN MICROBIOLOGY, 2019, 10
[3]   CD163 and Inflammation: Biological, Diagnostic, and Therapeutic Aspects [J].
Etzerodt, Anders ;
Moestrup, Soren K. .
ANTIOXIDANTS & REDOX SIGNALING, 2013, 18 (17) :2352-2363
[4]   Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [J].
Huang, Chaolin ;
Wang, Yeming ;
Li, Xingwang ;
Ren, Lili ;
Zhao, Jianping ;
Hu, Yi ;
Zhang, Li ;
Fan, Guohui ;
Xu, Jiuyang ;
Gu, Xiaoying ;
Cheng, Zhenshun ;
Yu, Ting ;
Xia, Jiaan ;
Wei, Yuan ;
Wu, Wenjuan ;
Xie, Xuelei ;
Yin, Wen ;
Li, Hui ;
Liu, Min ;
Xiao, Yan ;
Gao, Hong ;
Guo, Li ;
Xie, Jungang ;
Wang, Guangfa ;
Jiang, Rongmeng ;
Gao, Zhancheng ;
Jin, Qi ;
Wang, Jianwei ;
Cao, Bin .
LANCET, 2020, 395 (10223) :497-506
[5]   Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death [J].
Shi, Jianjin ;
Gao, Wenqing ;
Shao, Feng .
TRENDS IN BIOCHEMICAL SCIENCES, 2017, 42 (04) :245-254
[6]  
W.H.O, 2020, COR DIS COVID 2019 S
[7]   Effective treatment of severe COVID-19 patients with tocilizumab [J].
Xu, Xiaoling ;
Han, Mingfeng ;
Li, Tiantian ;
Sun, Wei ;
Wang, Dongsheng ;
Fu, Binqing ;
Zhou, Yonggang ;
Zheng, Xiaohu ;
Yang, Yun ;
Li, Xiuyong ;
Zhang, Xiaohua ;
Pan, Aijun ;
Wei, Haiming .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (20) :10970-10975
[8]   A role for mitochondria in NLRP3 inflammasome activation [J].
Zhou, Rongbin ;
Yazdi, Amir S. ;
Menu, Philippe ;
Tschopp, Juerg .
NATURE, 2011, 469 (7329) :221-225
[9]   Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients [J].
Zhou, Yonggang ;
Fu, Binqing ;
Zheng, Xiaohu ;
Wang, Dongsheng ;
Zhao, Changcheng ;
Qi, Yingjie ;
Sun, Rui ;
Tian, Zhigang ;
Xu, Xiaoling ;
Wei, Haiming .
NATIONAL SCIENCE REVIEW, 2020, 7 (06) :998-1002