A rapid improved method for gamma-spectrometric determination of 202Tl impurities in [201Tl]-labelled radiopharmaceuticals

被引：6
作者：
Bonardi, M
Groppi, F
Birattari, C
机构：
[1] Univ Milan, LASA, Accelerators & Appl Semiconduct Lab, Radiochem Lab, I-20090 Segrate, Italy
[2] Ist Nazl Fis Nucl, Natl Inst Nucl Phys, I-20090 Segrate, Italy
来源：
APPLIED RADIATION AND ISOTOPES | 2002年 / 57卷 / 05期
关键词：
(201)T1; (202)T1 impurity; gamma-spectrometry; absorption; sample shielding; dead time;
D O I：
10.1016/S0969-8043(02)00179-3
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Despite the cyclotron production method and the efficiency of the radiochemical procedures adopted, the long-lived radio-isotopic impurity Tl-202 is always present in [Tl-201]-labelled radio-pharmaceuticals, together with other short-lived impurities like, Tl-200. Rapid determination of the Tl-202 impurity, can be achieved using HPGe gamma spectrometry and a detector shielded by a 5 mm thick envelope of lead. In this way, dead-time correction errors, Compton and X-ray background, are very efficiently avoided and suppressed. The same method could be applied routinely in nuclear medicine, to determine the radioisotopic purity of Tl-201 by means of an ionisation chamber dose calibrator. (C) 2002 Elsevier Science Ltd. All rights reserved.
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收藏
页码：647 / 655
页数：9
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