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BALB/c and C57BL/6 Mice Differ in Polyreactive IgA Abundance, which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity
被引:226
作者:
Fransen, Floris
[1
,2
]
Zagato, Elena
[1
,2
]
Mazzini, Elisa
[1
,2
]
Fosso, Bruno
[3
]
Manzari, Caterina
[3
]
El Aidy, Sahar
[1
,2
,4
]
Chiavelli, Andrea
[1
,2
]
D'Erchia, Anna Maria
[5
]
Sethi, Maya K.
[6
]
Pabst, Oliver
[7
]
Marzano, Marinella
[3
]
Moretti, Silvia
[8
]
Romani, Luigina
[8
]
Penna, Giuseppe
[1
,2
]
Pesole, Graziano
[3
,5
]
Rescigno, Maria
[1
,2
,9
]
机构:
[1] IEO, Dept Expt Oncol, Via Adamello 16, I-20139 Milan, Italy
[2] IEO, Dept Expt Oncol, Via Adamello 16, I-20139 Milan, Italy
[3] IEO, Immunotherapy Programme, I-20139 Milan, Italy
[4] CNR, Inst Biomembranes & Bioenerget, I-70126 Bari, Italy
[5] Univ Groningen, Fac Math & Nat Sci, Groningen Biomol Sci & Biotechnol, NL-9700 CC Groningen, Netherlands
[6] Univ Bari, Dept Biosci Biotechnol & Biopharmaceut, I-70125 Bari, Italy
[7] Hannover Med Sch, Inst Immunol, D-30625 Hannover, Germany
[8] Rhein Westfal TH Aachen, Inst Mol Med, D-52074 Aachen, Germany
[9] Univ Perugia, Dept Expt Med, I-06132 Perugia, Italy
来源:
基金:
欧洲研究理事会;
关键词:
SEGMENTED FILAMENTOUS BACTERIA;
CD103(+) DENDRITIC CELLS;
IMMUNOGLOBULIN-A;
SECRETORY ANTIBODIES;
MUCOSAL SURFACES;
IMMUNE-RESPONSE;
GUT MICROBIOTA;
SALMONELLA;
HOMEOSTASIS;
SYSTEM;
D O I:
10.1016/j.immuni.2015.08.011
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
The interrelationship between IgAs and microbiota diversity is still unclear. Here we show that BALB/c mice had higher abundance and diversity of IgAs than C57BL/6 mice and that this correlated with increased microbiota diversity. We show that polyreactive IgAs mediated the entrance of non-invasive bacteria to Peyer's patches, independently of CX3CR1(+) phagocytes. This allowed the induction of bacteria-specific IgA and the establishment of a positive feedback loop of IgA production. Cohousing of mice or fecal transplantation had little or no influence on IgA production and had only partial impact on microbiota composition. Germ-free BALB/c, but not C57BL/6, mice already had polyreactive IgAs that influenced microbiota diversity and selection after colonization. Together, these data suggest that genetic predisposition to produce polyreactive IgAs has a strong impact on the generation of antigenspecific IgAs and the selection and maintenance of microbiota diversity.
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页码:527 / 540
页数:14
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