Individual and combined effects of deoxynivalenol and zearalenone on mouse kidney

被引：97

作者：

Liang, Zhen ^{[1
,2
,3
]}

Ren, Zhihua ^{[1
,2
,3
]}

Gao, Shuang ^{[1
,2
,3
]}

Chen, Yun ^{[1
,2
,3
]}

Yang, Yanyi ^{[1
,2
,3
]}

Yang, Dan ^{[1
,2
,3
]}

Deng, Junliang ^{[1
,2
,3
]}

Zuo, Zhicai ^{[1
,2
,3
]}

Wang, Ya ^{[1
,2
,3
]}

Shen, Liuhong ^{[1
,2
,3
]}

机构：

[1] Sichuan Agr Univ, Coll Vet Med, Yaan, Peoples R China

[2] Sichuan Prov Key Lab Anim Dis & Human Hlth, Yaan, Peoples R China

[3] Key Lab Environm Hazard & Human Hlth Sichuan Prov, Yaan 625014, Peoples R China

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2015年 / 40卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Deoxynivalenol; Zearalenone; Kidney; Oxidative stress; OXIDATIVE STRESS; MYCOTOXIN COMBINATIONS; APOPTOSIS; CELLS; FEED; TOXICITY; EXPOSURE; FOCUS;

D O I：

10.1016/j.etap.2015.08.029

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This study was performed to investigate the individual and combined toxic effects of deoxynivalenol (DON) and zearalenone (ZEA) on mouse kidney. A total of 360 female mice were divided into nine groups. Each group received intraperitoneal injection of solvent (control), DON, ZEA, or DON + ZEA four times for 12 d. Results showed that ZEA and/or DON increased the apoptosis rate in the kidney, as well as the levels of serum creatinine and blood urea nitrogen. DON and/or ZEA also induced renal oxidative stress as indicated by increased malondialdehyde concentration and nitric oxide level and reduced superoxide dismutase enzyme activity and hydroxyl radical inhibiting capacity. The observed changes were dose and time dependent. This study reports that DON and/or ZEA induced apoptosis, dysfunction, and oxidative stress in mouse kidney. Furthermore, the combination of DON + ZEA exhibited a sub-additive nephrotoxic effect. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：686 / 691

页数：6

共 38 条

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