Bladder cancer: new TUR techniques

被引:59
作者
Wilby, Daniel [1 ]
Thomas, Kay [1 ]
Ray, Eleanor [1 ]
Chappell, Barnaby [1 ]
O'Brien, Timothy [1 ]
机构
[1] Guys & St Thomas NHS Fdn Trust, Guys Hosp, Southwark Wing, Dept Urol, London, England
关键词
Bladder cancer; Bladder tumour; TURBT; REPEAT TRANSURETHRAL RESECTION; RECURRENCE RATE; T1; TUMORS; MANAGEMENT; CYSTOSCOPY; CARCINOMA; RISK;
D O I
10.1007/s00345-009-0398-9
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Transurethral resection of bladder tumours (TURBT) using a wire loop remains the gold-standard treatment for bladder tumours, but it is associated with unacceptably high early recurrence rates after first resection. Improvements to standard resection techniques and a range of optical and technological advances offer exciting possibilities for improving outcomes. Early second resection has been shown to reduce recurrence rates, and increase response to intravesical chemotherapy and/or immunotherapy. It should be considered in most high-risk non-muscle invasive cancers (T1; G3; multifocal) being managed by bladder conservation. Newer energy sources, such as laser, may facilitate day case management of bladder tumours using local anaesthesia in select groups of patients. The novel technique of photodynamic diagnosis improves tumour detection, and quality of resection, and is likely to become the standard for initial tumour management. The traditional 'incise and scatter' resection technique goes against all oncological surgical principles. En-bloc resection of tumours would be far preferable and demands further development and evaluation. The technique of TURBT needs to evolve to allow first-time clearance of disease and low recurrence rates.
引用
收藏
页码:309 / 312
页数:4
相关论文
共 30 条
[1]   5-aminolaevulinic acid-induced fluorescence cystoscopy during transurethral resection reduces the risk of recurrence in stage Ta/T1 bladder cancer [J].
Babjuk, M ;
Soukup, V ;
Petrík, R ;
Jirsa, M ;
Dvorácek, J .
BJU INTERNATIONAL, 2005, 96 (06) :798-802
[2]  
BOYD PJR, 1974, LANCET, V2, P1290
[3]   Variability in the recurrence rate at first follow-up cystoscopy after TUR in stage Ta T1 transitional cell carcinoma of the bladder: A combined analysis of seven EORTC studies [J].
Brausi, M ;
Collette, L ;
Kurth, K ;
van der Meijden, AP ;
Oosterlinck, W ;
Witjes, JA ;
Newling, D ;
Bouffioux, C ;
Sylvester, RJ .
EUROPEAN UROLOGY, 2002, 41 (05) :523-530
[4]  
Das A, 1998, Tech Urol, V4, P12
[5]   The effect of repeat transurethral resection on recurrence and progression rates in patients with T1 tumors of the bladder who received intravesical mitomycin:: A prospective, randomized clinical trial [J].
Divrik, RT ;
Yildirim, Ü ;
Zorlu, F ;
Özen, H .
JOURNAL OF UROLOGY, 2006, 175 (05) :1641-1644
[6]   Clinically relevant improvement of recurrence-free survival with 5-aminolevulinic acid induced fluorescence diagnosis in patients with superficial bladder tumors [J].
Filbeck, T ;
Pichlmeier, U ;
Knuechel, R ;
Wieland, WF ;
Roessler, W .
JOURNAL OF UROLOGY, 2002, 168 (01) :67-71
[7]  
FRAUNDORFER M, 1997, BR J UROL, V80, P39
[8]   Effect of routine repeat transurethral resection for superficial bladder cancer:: A long-term observational study [J].
Grimm, MO ;
Steinhoff, C ;
Simon, X ;
Spiegelhalder, P ;
Ackermann, R ;
Vögeli, TA .
JOURNAL OF UROLOGY, 2003, 170 (02) :433-437
[9]   Evidence for oligoclonality and tumor spread by intraluminal seeding in multifocal urothelial carcinomas of the upper and lower urinary tract [J].
Hafner, C ;
Knuechel, R ;
Zanardo, L ;
Dietmaier, W ;
Blaszyk, H ;
Cheville, J ;
Hofstaedter, F ;
Hartmann, A .
ONCOGENE, 2001, 20 (35) :4910-4915
[10]   The value of a second transurethral resection in evaluating patients with bladder tumors [J].
Herr, HW .
JOURNAL OF UROLOGY, 1999, 162 (01) :74-76