Highly oxygenated lanostane triterpenoids from Ganoderma applanatum as a class of agents for inhibiting lipid accumulation in adipocytes

被引：13

作者：

Su, Hai-Guo ^{[1
,2
]}

Wang, Qian ^{[1
,2
]}

Zhou, Lin ^{[1
]}

Peng, Xing-Rong ^{[1
]}

Xiong, Wen-Yong ^{[1
,3
]}

Qiu, Ming-Hua ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Yunnan Univ, Key Lab Med Chem Nat Resource, Kunming 650500, Yunnan, Peoples R China

来源：

BIOORGANIC CHEMISTRY | 2020年 / 104卷

基金：

中国国家自然科学基金;

关键词：

Ganoderma applanatum; Lanostane triterpenoids; Obesity; 3T3-L1; adipocytes; Antiadipogenic effects; FRUITING BODIES; OBESITY; LUCIDUM; DIFFERENTIATION;

D O I：

10.1016/j.bioorg.2020.104263

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ganoderma triterpenoids (GTs), a class of major active constituents in Ganoderma species, play an important role in the anti-obesity effect of Ganoderma fungi. In the study, seventeen new highly oxygenated lanostane tri-terpenoids, ganoapplanoids A-Q (1-17), together with five previously reported compounds (18-22), were isolated from the fruiting bodies of Ganoderma applanatum. Their structures were confirmed by comprehensive spectroscopic analyses, single-crystal X-ray diffraction and Mo-2(OAc)(4) induced CD cotton effect. Structurally, compound 6 represents the first example of 2-norlanostane triterpenoid possessing an unusual semiacetal moiety. Furthermore, isolates (1-5, 7-11, 13-22, 3a) were evaluated for regulatory effects on lipid accumulation by 3T3-L1 adipocytes model. Among them, compounds 11 and 17 exhibited significant potency in blunted adipogenesis activities dose-dependently. Meanwhile, compounds 11 and 17 reduced triglyceride (TG) and total cholesterol (TC) levels in the adipocytes. These results supported that the highly oxygenated lanostane tri-terpenoids from G. applanatum may serve as agents for inhibiting the lipid accumulation in adipocytes and the G. applanatum provided an important source for searching new drugs to treat obesity.

引用

页数：13

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