Principles of RNA methylation and their implications for biology and medicine

被引：94
作者：
Zhou, Yujia [1 ,2 ]
Kong, Ying [5 ]
Fan, Wenguo [6 ]
Tao, Tao [4 ]
Xiao, Qin [7 ]
Li, Na [3 ]
Zhu, Xiao [1 ,2 ,8 ,9 ]
机构：
[1] Guangdong Med Univ, Marine Biomed Res Inst, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang, Peoples R China
[2] Marine Biomed Res Inst Guangdong Zhanjiang, Zhanjiang, Peoples R China
[3] Chongqing Med Univ, Coll Basic Med, Chongqing, Peoples R China
[4] Zibo Cent Hosp, Dept Gastroenterol, Zibo, Peoples R China
[5] Jianghan Univ, Dept Clin Lab, Hubei 3 Peoples Hosp, Wuhan, Peoples R China
[6] Sun Yat Sen Univ, Hosp Stomatol, Dept Anesthesiol, Guangzhou, Peoples R China
[7] Peking Univ, Dept Blood Transfus, Shenzhen Hosp, Shenzhen, Peoples R China
[8] Guangdong Med Univ, Key Lab Zhanjiang R&D Marine Microbial Resources, Zhanjiang, Peoples R China
[9] Southern Marine Sci & Engn Guangdong Lab Zhanjian, Zhanjiang, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2020年 / 131卷
基金：
中国国家自然科学基金;
关键词：
RNA methylation; m6A; Regulators; Biological function; Cancer; HEME OXYGENASE-1 SYSTEM; CANCER STEM-CELLS; MESSENGER-RNA; DEMETHYLASE ALKBH5; HEPATOCELLULAR-CARCINOMA; FAT MASS; GENE-EXPRESSION; BREAST-CANCER; SELF-RENEWAL; NUCLEAR-RNA;
D O I：
10.1016/j.biopha.2020.110731
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
RNA methylation is a post-transcriptional level of regulation. At present, more than 150 kinds of RNA modifications have been identified. They are widely distributed in messenger RNA (mRNA), transfer RNA (tRNA), ribosomal RNA (rRNA), noncoding small RNA (sncRNA) and long-chain non-coding RNA (lncRNA). In recent years, with the discovery of RNA methylation related proteins and the development of high-throughput sequencing technology, the mystery of RNA methylation has been gradually revealed, and its biological function and application value have gradually emerged. In this review, a large number of research results of RNA methylation in recent years are collected. Through systematic summary and refinement, this review introduced RNA methylation modification-related proteins and RNA methylation sequencing technologies, as well as the biological functions of RNA methylation, expressions and applications of RNA methylation-related genes in physiological or pathological states such as cancer, immunity and virus infection, and discussed the potential therapeutic strategies.
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页数：22
相关论文
共 210 条
[1]   RNA Methylation by the MIS Complex Regulates a Cell Fate Decision in Yeast [J].
Agarwala, Sudeep D. ;
Blitzblau, Hannah G. ;
Hochwagen, Andreas ;
Fink, Gerald R. .
PLOS GENETICS, 2012, 8 (06)
[2]   Coordination of m6A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming [J].
Aguilo, Francesca ;
Zhang, Fan ;
Sancho, Ana ;
Fidalgo, Miguel ;
Di Cecilia, Serena ;
Vashisht, Ajay ;
Lee, Dung-Fang ;
Chen, Chih-Hung ;
Rengasamy, Madhumitha ;
Andino, Blanca ;
Jahouh, Farid ;
Roman, Angel ;
Krig, Sheryl R. ;
Wang, Rong ;
Zhang, Weijia ;
Wohlschlegel, James A. ;
Wang, Jianlong ;
Walsh, Martin J. .
CELL STEM CELL, 2015, 17 (06) :689-704
[3]   Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation [J].
Aik, WeiShen ;
Scotti, John S. ;
Choi, Hwanho ;
Gong, Lingzhi ;
Demetriades, Marina ;
Schofield, Christopher J. ;
McDonough, Michael A. .
NUCLEIC ACIDS RESEARCH, 2014, 42 (07) :4741-4754
[4]   CD66 and CD49f expressing cells are associated with distinct neoplastic phenotypes and progression in human cervical cancer [J].
Ammothumkandy, Aswathy ;
Maliekal, Tessy Thomas ;
Bose, Mayil Vahanan ;
Rajkumar, Thangarajan ;
Shirley, Sundersingh ;
Thejaswini, B. ;
Giri, Venkat G. ;
Krishna, Sudhir .
EUROPEAN JOURNAL OF CANCER, 2016, 60 :166-178
[5]   Method of the Year 2016: Epitranscriptome analysis [J].
不详 .
NATURE METHODS, 2017, 14 (01) :1-1
[6]  
[Anonymous], 2018, BIOL MA MRNA METHYLA, V20, P1074
[7]   YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma [J].
Bai, Yang ;
Yang, Chunxing ;
Wu, Runliu ;
Huang, Lihua ;
Song, Shenlei ;
Li, Wanwan ;
Yan, Peichen ;
Lin, Changwei ;
Li, Daojiang ;
Zhang, Yi .
FRONTIERS IN ONCOLOGY, 2019, 9
[8]   Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control [J].
Barbieri, Isaia ;
Tzelepis, Konstantinos ;
Pandolfini, Luca ;
Shi, Junwei ;
Millan-Zambrano, Gonzalo ;
Robson, Samuel C. ;
Aspris, Demetrios ;
Migliori, Valentina ;
Bannister, Andrew J. ;
Han, Namshik ;
De Braekeleer, Etienne ;
Ponstingl, Hannes ;
Hendrick, Alan ;
Vakoc, Christopher R. ;
Vassiliou, George S. ;
Kouzarides, Tony .
NATURE, 2017, 552 (7683) :126-+
[9]   m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells [J].
Batista, Pedro J. ;
Molinie, Benoit ;
Wang, Jinkai ;
Qu, Kun ;
Zhang, Jiajing ;
Li, Lingjie ;
Bouley, Donna M. ;
Lujan, Ernesto ;
Haddad, Bahareh ;
Daneshvar, Kaveh ;
Carter, Ava C. ;
Flynn, Ryan A. ;
Zhou, Chan ;
Lim, Kok-Seong ;
Dedon, Peter ;
Wernig, Marius ;
Mullen, Alan C. ;
Xing, Yi ;
Giallourakis, Cosmas C. ;
Chang, Howard Y. .
CELL STEM CELL, 2014, 15 (06) :707-719
[10]   Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome [J].
Boulias, Konstantinos ;
Toczydlowska-Socha, Diana ;
Hawley, Ben R. ;
Liberman, Noa ;
Takashima, Ken ;
Zaccara, Sara ;
Guez, Theo ;
Vasseur, Jean-Jacques ;
Debart, Francoise ;
Aravind, L. ;
Jaffrey, Samie R. ;
Greer, Eric Lieberman .
MOLECULAR CELL, 2019, 75 (03) :631-+
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