The epigenetic tracks of aging

被引：48

作者：

Weidner, Carola Ingrid ^{[1
]}

Wagner, Wolfgang ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Sch Med, Helmholtz Inst Biomed Engn Stem Cell Biol & Cellu, D-52074 Aachen, Germany

来源：

BIOLOGICAL CHEMISTRY | 2014年 / 395卷 / 11期

关键词：

aging; biological age; chromatin; DNA-methylation; histone; predictor; DNA-METHYLATION CHANGES; PLURIPOTENT STEM-CELLS; HISTONE MODIFICATIONS; HUMAN TISSUES; LIFE-SPAN; AGE; WIDE; SENESCENCE; EXPRESSION; GENE;

D O I：

10.1515/hsz-2014-0180

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging is associated with the deterioration of biological functions, which is either caused by accumulation of random defects or mediated by a controlled process. This article provides an overview of age-associated epigenetic alterations in the histone code, DNA-methylation (DNAm) pattern, and chromatin structure. In particular, age-related DNAm changes are highly reproducible at specific sites in the genome. The DNAm level at few CpGs facilitates estimation of chronological age and there is evidence that such predictions are indicative for biological age. Overall, aging appears to be associated with a tightly regulated epigenetic process, but the underlying mechanism remains to be elucidated.

引用

页码：1307 / 1314

页数：8

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