miR-143 Inhibits NSCLC Cell Growth and Metastasis by Targeting Limk1

被引：49
|
作者：
Xia, Hui [1 ]
Sun, Shengjie [2 ]
Wang, Bo [3 ]
Wang, Tao [3 ]
Liang, Chaoyang [3 ]
Li, Guo [3 ]
Huang, Chongbiao [4 ]
Qi, Daliang [4 ]
Chu, Xiangyang [3 ]
机构：
[1] Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Thorac Cardio Surg, Beijing 100048, Peoples R China
[2] Gen Hosp Peoples Liberat Army, Dept Med Oncol, Beijing 100853, Peoples R China
[3] Gen Hosp Peoples Liberat Army, Dept Thorac Surg, Beijing 100853, Peoples R China
[4] Tianjin Med Univ, Canc Inst & Hosp, Dept Senior Ward, Key Lab Canc Prevent & Therapy Tianjin, Tianjin 300060, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2014年 / 15卷 / 07期
关键词：
miR-143; NSCLC; Limk1; proliferation; migration; invasion; LUNG-CANCER CELLS; DOWN-REGULATION; MICRORNA-143; PROLIFERATION; EXPRESSION; MIGRATION; DIAGNOSIS; MOTILITY; INVASION;
D O I：
10.3390/ijms150711973
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MicroRNAs (miRNAs) have essential roles in carcinogenesis and tumor progression. Here, we investigated the roles and mechanisms of miR-143 in non-small cell lung cancer (NSCLC). miR-143 was significantly decreased in NSCLC tissues and cell lines. Overexpression of miR-143 suppressed NSCLC cell proliferation, induced apoptosis, and inhibited migration and invasion in vitro. Integrated analysis identified LIM domain kinase 1 (Limk1) as a direct and functional target of miR-143. Overexpression of Limk1 attenuated the tumor suppressive effects of miR-143 in NSCLC cells. Moreover, miR-143 was inversely correlated with Limk1 expression in NSCLC tissues. Together, our results highlight the significance of miR-143 and Limk1 in the development and progression of NSCLC.
引用
收藏
页码：11973 / 11983
页数：11
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