Rhodium-Catalyzed Allylation Reactions

被引：56

作者：

Thoke, Mahesh Bhagwan ^{[1
,2
]}

Kang, Qiang ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Coal Ethylene Glycol & Its Related Techno, Ctr Excellence Mol Synth, Fujian Inst Res Struct Matter, 155 Yangqiao Rd West, Fuzhou 350002, Fujian, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2019年 / 51卷 / 13期

关键词：

rhodium; allylation; substitution; enantioselective; natural product synthesis; RING-OPENING REACTIONS; REGIOSELECTIVE DECARBOXYLATIVE ADDITION; ALLYLIC ALKYLATION REACTIONS; ACYL ANION EQUIVALENT; OXABICYCLIC ALKENES; ENANTIOSELECTIVE SYNTHESIS; TERMINAL ALKYNES; DIASTEREOSPECIFIC CONSTRUCTION; INTERMOLECULAR HYDROAMINATION; STEREOSPECIFIC CONSTRUCTION;

D O I：

10.1055/s-0037-1611784

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rhodium-catalyzed allylation reactions are well known for their unique selectivity and reactivity due to the high memory effect of Rh as compared to other metals. These reactions involve the substitution of allylic rhodium intermediates with a diverse range of different nucleophiles, leading to C-C and C-heteroatom bond formation. Modern organic chemists are, however, interested in atom-economical protocols under greener pathways and following recent increased understanding of mechanistic aspects of Rh-catalyzed allylation via the hydrofunctionalization of allenes or alkynes, great strides have made in the design and development of new atom-economical protocols. In this article, we review this field from its beginning to current state. 1 Introduction 2 Rhodium-Catalyzed Allylic Substitution 3 Rhodium-Catalyzed Allylation with Allenes 4 Rhodium-Catalyzed Allylation with Alkynes 5 Rhodium-Catalyzed Allylation with Dienes 6 Rhodium-Catalyzed Allylation by ARO of Oxabicyclic Alkenes 7 Rhodium-Catalyzed Enantioselective Allylation in Natural Product and Drug Synthesis 8 Conclusion

引用

页码：2585 / 2631

页数：47