Stem cell-based organ replacements-Airway and lung tissue engineering

被引：33

作者：

Fishman, Jonathan M. ^{[1
,2
,3
]}

Lowdell, Mark ^{[4
]}

Birchall, Martin A. ^{[1
,2
,3
]}

机构：

[1] UCL Ctr Stem Cells Tissue Engn & Regenerat Med, London, England

[2] Royal Natl Throat Nose & Ear Hosp, London WC1X 8DA, England

[3] UCL, UCL Ear Inst, London WC1X 8EE, England

[4] UCL, Royal Free Hosp, Dept Haematol, London, England

来源：

SEMINARS IN PEDIATRIC SURGERY | 2014年 / 23卷 / 03期

基金：

英国医学研究理事会;

关键词：

Airway management; Artificial organs; Biocompatible materials; Bioreactors; Larynx; Regenerative medicine; Stem cells; Tissue engineering; Tissue scaffolds; Trachea; Transplantation; PROOF-OF-CONCEPT; SEE VOL. 511; REGENERATIVE MEDICINE; EXTRACELLULAR-MATRIX; IN-VIVO; FOLLOW-UP; LARYNGEAL TRANSPLANTATION; ORTHOTOPIC TRANSPLANTATION; TONGUE TRANSPLANTATION; TRACHEAL REPLACEMENT;

D O I：

10.1053/j.sempedsurg.2014.04.002

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Tissue engineering requires the use of cells seeded onto scaffolds, often in conjunction with bioactive molecules, to regenerate or replace tissues. Significant advances have been made in recent years within the fields of stem cell biology and biomaterials, leading to some exciting developments in airway tissue engineering, including the first use of stem cell-based tissue-engineered tracheal replacements in humans. In addition, recent advances within the fields of scaffold biology and decellularization offer the potential to transplant patients without the use of immunosuppression. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：119 / 126

页数：8

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