Highly Enantioselective Copper-Catalyzed Propargylic Substitution of Propargylic Acetates with 1,3-Dicarbonyl Compounds

被引：53
|
作者：
Han, Fu-Zhong [1 ,2 ]
Zhu, Fu-Lin [2 ]
Wang, Ya-Hui [2 ]
Zou, Yuan [2 ]
Hu, Xin-Hu [2 ]
Chen, Song [2 ]
Hu, Xiang-Ping [2 ]
机构：
[1] Qiqihar Univ, Coll Chem & Chem Engn, Qiqihar 161006, Peoples R China
[2] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 02期
关键词：
ALLYLIC ALKYLATIONS; ALCOHOLS; AMINATION; AMINES; ESTERS; ORGANOCATALYSTS; DERIVATIVES; COMPLEXES; ALDEHYDES; LIGANDS;
D O I：
10.1021/ol403469m
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A chiral tridentate ketimine P,N,N-ligand has been successfully applied in the copper-catalyzed enantioselective propargylic substitution of propargylic acetates with a variety of beta-dicarbonyl compounds, in which excellent enantioselectivities (up to >99% ee) and high yields have been obtained.
引用
收藏
页码：588 / 591
页数：4
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