Basal cytokeratin expression in relation to immunohistochemical and clinical characterization in breast cancer patients with triple negative phenotype

被引：1

作者：

Liu, Zhe-Bin ^{[1
,3
]}

Wu, Jiong ^{[1
,3
]}

Ping, Bo ^{[2
,3
]}

Feng, Li-Qing ^{[2
,3
]}

Di, Gen-Hong ^{[1
,3
]}

Lu, Jin-Song ^{[1
,3
]}

Shen, Kun-Wei ^{[1
,3
]}

Shen, Zhen-Zhou ^{[1
,3
]}

Shao, Zhi-Min ^{[1
,3
]}

机构：

[1] Fudan Univ, Breast Canc Inst, Dept Breast Surg, Shanghai 200032, Peoples R China

[2] Fudan Univ, Canc Hosp, Inst Canc, Dept Pathol, Shanghai 200032, Peoples R China

[3] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China

来源：

TUMORI JOURNAL | 2009年 / 95卷 / 01期

关键词：

breast neoplasm; basal; keratin; prognosis; PROGNOSTIC-FACTORS; PATTERNS; MARKERS; CLASSIFICATION; SURVIVAL; SUBTYPES; BENIGN; TUMORS; MODEL;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aims and background. To evaluate the immunohistochemical characterization of CK5/6 and CK17 and whether the expression level of the two markers was correlated with clinical outcome or pathological feature in triple negative (ER-, PR-, HER-2-) patients with breast cancer. Methods and study design. We carried out an immunohistochemical assay for CK5/6 and CK17 markers on formalin-fixed invasive carcinoma samples from 112 patients who were diagnosed between 2000 and 2002. All of them had an immunohistochemical triple negative status and follow-Lip information available. Results. Of the 112 patients characterized by triple negative immunohistochemical status, 82 (73.2%) were disease free with no relapse or metastasis. In total, CK5/6 and CK17 were both determined positive in 33.9% (38/112) of the 112 tumor samples, and 46.4% (52/112) were regarded as positive for CK5/6 or CK17. The Kaplan-Meier Curve showed that positive staining for CK5/6, CK17, or CK which means CK5/6 positive or CK17 positive, was associated with worse disease-free survival (P = 0.020, P = 0.032, P = 0.003), and positive staining for CK5/6 or CK was associated with worse overall survival (P = 0.027, P = 0.015). When we considered 91 patients whose pathological type was invasive ductal carcinoma, we found that there was also an association between CK5/6 or CK17 immunostaining and high grade (P = 0.030). In addition, these two markers were also associated with axillary lymph node status (P = 0.044). The Cox regression multiple-factor analysis showed that pathological stage, grade and expression of CK were the factors affecting both disease-free and overall survival, whereas age and menopausal status were independent factors affecting disease-free and overall survival, respectively. Conclusions. Positive staining for CK5/6 or CK17 was associated with a worse prognosis, high tumor grade and positive axillary lymph nodes,

引用

页码：53 / 62

页数：10

共 31 条

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