DISC1, PDE4B, and NDE1 at the centrosome and synapse

被引：66

作者：

Bradshaw, Nicholas J. ^{[1
]}

Ogawa, Fumiaki ^{[1
]}

Antolin-Fontes, Beatriz ^{[1
]}

Chubb, Jennifer E. ^{[1
]}

Carlyle, Becky C. ^{[1
]}

Christie, Sheila ^{[1
]}

Claessens, Antoine ^{[1
,2
]}

Porteous, David J. ^{[1
]}

Millar, J. Kirsty ^{[1
]}

机构：

[1] Mol Med Ctr, Med Genet Sect, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Univ Edinburgh, Ashworth Labs, Inst Immunol & Infect Res, Edinburgh EH9 3JT, Midlothian, Scotland

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 377卷 / 04期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

DISC1; PDE4; LIS1; NDEL1; NDE1; Schizophrenia; Centrosome; Synapse;

D O I：

10.1016/j.bbrc.2008.10.120

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Disrupted-In-Schizophrenia 1 (DISC1) is a risk factor for schizophrenia and other major mental illnesses. Its protein binding partners include the Nuclear Distribution Factor E Homologs (NDE1 and NDEL1), LIS1, and phosphodiesterases 4B and 4D (PDE4B and PDE4D). We demonstrate that NDE1, NDEL1 and LIS1, together with their binding partner dynein, associate with DISC1, PDE4B and PDE4D within the cell, and provide evidence that this complex is present at the centrosome. LIS1 and NDEL1 have been previously Suggested to be synaptic, and we now demonstrate localisation of DISC1, NDE1, and PDE4B at synapses in Cultured neurons. NDE1 is phosphorylated by cAMP-dependant Protein Kinase A (PKA), whose activity is, in turn, regulated by the cAMP hydrolysis activity of phosphodiesterases, including PDE4. We propose that DISCI acts as an assembly scaffold for all of these proteins and that the NDE1/NDEL1/LIS1/dynein complex is modulated by cAMP levels via PKA and PDE4. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1091 / 1096

页数：6

共 30 条

[1]

BRADSHAW NJ, NEUROSCI LE IN PRESS

[2] Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders [J].

Brandon, NJ ;

Handford, EJ ;

Schurov, I ;

Rain, JC ;

Pelling, M ;

Duran-Jimeniz, B ;

Camargo, LM ;

Oliver, KR ;

Beher, D ;

Shearman, MS ;

Whiting, PJ .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2004, 25 (01) :42-55

[3] Elucidating the relationship between DISC1, NDEL1and NDE1 and the risk for schizophrenia:: Evidence of epistasis and competitive binding [J].

Burdick, Katherine E. ;

Kamiya, Atsushi ;

Hodgkinson, Colin A. ;

Lencz, Todd ;

DeRosse, Pamela ;

Ishizuka, Koko ;

Elashvili, Sarah ;

Arai, Hiroyuki ;

Goldman, David ;

Sawa, Akira ;

Malhotra, Anil K. .

HUMAN MOLECULAR GENETICS, 2008, 17 (16) :2462-2473

[4] The DISC locus in psychiatric illness [J].

Chubb, J. E. ;

Bradshaw, N. J. ;

Soares, D. C. ;

Porteous, D. J. ;

Millar, J. K. .

MOLECULAR PSYCHIATRY, 2008, 13 (01) :36-64

[5] Behavioral phenotypes of Disc1 missense mutations in mice [J].

Clapcote, Steven J. ;

Lipina, Tatiana V. ;

Millar, J. Kirsty ;

Mackie, Shaun ;

Christie, Sheila ;

Ogawa, Fumiaki ;

Lerch, Jason P. ;

Trimble, Keith ;

Uchiyama, Masashi ;

Sakuraba, Yoshiyuki ;

Kaneda, Hideki ;

Shiroishi, Toshihiko ;

Houslay, Miles D. ;

Henkelman, R. Mark ;

Sled, John G. ;

Gondo, Yoichi ;

Porteous, David J. ;

Roder, John C. .

NEURON, 2007, 54 (03) :387-402

[6] The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly [J].

Derewenda, Urszula ;

Tarricone, Cataldo ;

Choi, Won Chan ;

Cooper, David R. ;

Lukasik, Steve ;

Perrina, Franco ;

Tripathy, Ashutosh ;

Kim, Myung Hee ;

Cafiso, David S. ;

Musacchio, Andrea ;

Derewenda, Zygmunt S. .

STRUCTURE, 2007, 15 (11) :1467-1481

[7] Disrupted-in-schizophrenia 1 regulates integration of newly generated neurons in the adult brain [J].

Duan, Xin ;

Chang, Jay H. ;

Ge, Shaoyu ;

Faulkner, Regina L. ;

Kim, Ju Young ;

Kitabatake, Yasuji ;

Liu, Xiao-bo ;

Yang, Chih-Hao ;

Jordan, J. Dedrick ;

Ma, Dengke K. ;

Liu, Cindy Y. ;

Ganesan, Sundar ;

Cheng, Hwai-Jong ;

Ming, Guo-li ;

Lu, Bai ;

Song, Hongjun .

CELL, 2007, 130 (06) :1146-1158

[8] Leptin regulation of bone resorption by the sympathetic nervous system and CART [J].

Elefteriou, F ;

Ahn, JD ;

Takeda, S ;

Starbuck, M ;

Yang, XL ;

Liu, XY ;

Kondo, H ;

Richards, WG ;

Bannon, TW ;

Noda, M ;

Clement, K ;

Vaisse, C ;

Karsenty, G .

NATURE, 2005, 434 (7032) :514-520

[9] PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia [J].

Fatemi, S. Hossein ;

King, David P. ;

Reutiman, Teri J. ;

Folsom, Timothy D. ;

Laurence, Jessica A. ;

Lee, Susanne ;

Fan, Yu-Ti ;

Paciga, Sara A. ;

Conti, Marco ;

Menniti, Frank S. .

SCHIZOPHRENIA RESEARCH, 2008, 101 (1-3) :36-49

[10] Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1 [J].

Hennah, William ;

Tomppo, Liisa ;

Hiekkalinna, Tero ;

Palo, Outi M. ;

Kilpinen, Helena ;

Ekelund, Jesper ;

Tuulio-Henriksson, Annamari ;

Silander, Kaisa ;

Partonen, Timo ;

Paunio, Tiina ;

Terwilliger, Joseph D. ;

Lonnqvist, Jouko ;

Peltonen, Leena .

HUMAN MOLECULAR GENETICS, 2007, 16 (05) :453-462

← 1 2 3 →