Hippocampal volume in first episode and recurrent depression

被引:74
作者
Kronmueller, Klaus-Thomas [1 ]
Schroeder, Johannes [2 ]
Koehler, Sebastian [1 ]
Goetz, Bianca [1 ]
Victor, Daniela [1 ]
Unger, Joerg [1 ]
Giesel, Frederic [3 ]
Magnotta, Vincent [4 ]
Mundt, Christoph [1 ]
Essig, Marco [3 ]
Pantel, Johannes [5 ]
机构
[1] Heidelberg Univ, Dept Psychiat, D-69115 Heidelberg, Germany
[2] Heidelberg Univ, Sect Geriatr Psychiat, D-69115 Heidelberg, Germany
[3] German Canc Res Ctr, Dept Radiol, D-6900 Heidelberg, Germany
[4] Univ Iowa, Dept Psychiat, Mental Hlth Clin Res Ctr, Iowa City, IA 52242 USA
[5] Univ Frankfurt Main, Dept Psychiat & Psychotherapy, Mainz, Germany
关键词
Affective disorders; Structural brain imaging; Gender effects; POSTTRAUMATIC-STRESS-DISORDER; AMYGDALA VOLUMES; MAJOR DEPRESSION; METAANALYSIS; REDUCTION; WOMEN; 1ST-EPISODE; ADULTS; ONSET; YOUNG;
D O I
10.1016/j.pscychresns.2008.08.001
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Abnormalities in limbic-thalamic-cortical networks are hypothesized to modulate human mood states In the present study differences in hippocampal volumes of patients with a first episode of depression, recurrent major depression and healthy control subjects were examined with high-resolution magnetic resonance imaging (MRI). Male patients with a first episode of major depression had a significantly smaller left hippocampal volume than male control subjects. Also, these patients had a significant left-right asymmetry in hippocampal volume. Female patients showed no significant alterations in hippocampal volumes. The results support the hypothesis that the hippocampus plays an important role in the pathophysiology of the early phase of major depression, especially for male patients. Implications for the neurodevelopmental and the neurodegenerative model of hippocampal change are discussed. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:62 / 66
页数:5
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