Printable smart 3D architectures of regenerated silk on poly (3-hydroxybutyrate-co-3-hydroxyvalerate)

被引：24

作者：

Bon, Silvia Bittolo ^{[1
,2
]}

Chiesa, Irene ^{[3
,4
]}

Morselli, Davide ^{[2
,5
]}

Degli Esposti, Micaela ^{[2
,5
]}

Fabbri, Paola ^{[2
,5
]}

De Maria, Carmelo ^{[3
,4
]}

Viligiardi, Tommaso Foggi ^{[6
]}

Morabito, Antonino ^{[6
,7
]}

Giorgi, Giacomo ^{[8
,9
]}

Valentini, Luca ^{[1
,2
]}

机构：

[1] Univ Perugia, Dipartimento Ingn Civile & Ambientale, Str Pentima 4, I-05100 Terni, Italy

[2] Italian Consortium Sci & Technol Mat INSTM, Via Giusti 9, I-50121 Florence, Italy

[3] Univ Pisa, Dept Ingn Informaz, Largo Lucio Lazzarino 1, I-56122 Pisa, Italy

[4] Univ Pisa, Res Ctr E Piaggio, Largo Lucio Lazzarino 1, I-56122 Pisa, Italy

[5] Univ Bologna, Dept Civil Chem Environm & Mat Engn DICAM, Via Terracini 28, I-40131 Bologna, Italy

[6] Meyer Childrens Hosp, Dept Pediat Surg, Viale Pieraccini 24, I-50139 Florence, Italy

[7] Univ Firenze, Dipartimento Neurosci, Psicol, Area Farmaco & Salute Bambino NEUROFARBA, Viale Pieraccini 6, I-50121 Florence, Italy

[8] Univ Perugia, Dipartimento Ingn Civile & Ambientale DICA, Via G Duranti 93, I-06125 Perugia, Italy

[9] CNR SCITEC, I-06123 Perugia, Italy

来源：

MATERIALS & DESIGN | 2021年 / 201卷

关键词：

3D printing; Finite element analysis; Regenerated silk; PHBV; Sutureless device; Piezoelectric properties; FIBROIN; POLYHYDROXYALKANOATES; MULTIMATERIAL; ANASTOMOSIS; SCAFFOLDS; MECHANISM; GELATION; FORMS;

D O I：

10.1016/j.matdes.2021.109492

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

YIn this study, we report the fabrication of two different three-dimensional (3D) architectures of regenerated silk (RS) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) with embedded functionalities. 3D printed cylinders with an internal layer of PHBV and an external of calcium ions (Ca++) or potassium nitrate (KNO3) modified RS were designed to control the radial shrinkage, water uptake and compression strength. Such cylinders were then used as sutureless thermoresponsive clips, measuring the bursting resistance once applied on an anastomized porcine intestine. Experimental data are supported by finite element simulations that model the tube contraction, demonstrating the possibility to program the shape-changing behavior of 3D printed structures. Printing RS on PHBV, we obtained responsive 3D grids to external force with self-powering properties. The synergic effect obtained by combining materials on appropriate architectures paves the way to potential clinical applications ranging from monitoring of vital signs to sutureless sealant patches. (C) 2021 The Authors. Published by Elsevier Ltd.

引用

页数：9

共 43 条

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