Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes

被引：68

作者：

Doody, Karen M. ^{[1
]}

Bottini, Nunzio ^{[2
]}

Firestein, Gary S. ^{[2
]}

机构：

[1] Mem Univ Newfoundland, Grenfell Campus, Corner Brook, NF, Canada

[2] Univ Calif San Diego, Sch Med, Div Rheumatol Allergy & Immunol, La Jolla, CA 92093 USA

来源：

EPIGENOMICS | 2017年 / 9卷 / 04期

关键词：

epigenetics; fibroblast-like synoviocytes; histone; methylation; microRNA; rheumatoid arthritis; HISTONE DEACETYLASE INHIBITORS; DNA METHYLOME SIGNATURE; SYNOVIAL FIBROBLASTS; ALTERED EXPRESSION; TRICHOSTATIN-A; KEY REGULATOR; MOUSE MODEL; METHYLATION; MICRORNA; RISK;

D O I：

10.2217/epi-2016-0151

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Rheumatoid arthritis is an immune-mediated disease that primarily affects diarthrodial joints. Susceptibility and severity of this disease are influenced by nongenetic factors, such as environmental stress, suggesting an important role of epigenetic changes. In this review, we summarize the epigenetic changes (DNA methylation, histone modification and miRNA expression) in fibroblast-like synoviocytes, which are the joint-lining mesenchymal cells that play an important role in joint inflammation and damage. We also review the effects of these epigenetic changes on rheumatoid arthritis pathogenesis and discuss their therapeutic potential.

引用

页码：479 / 492

页数：14

共 97 条

[71] miR-346 Controls Release of TNF-α Protein and Stability of Its mRNA in Rheumatoid Arthritis via Tristetraprolin Stabilization [J].

Semaan, Noha ;

Frenzel, Laurent ;

Alsaleh, Ghada ;

Suffert, Guillaume ;

Gottenberg, Jacques-Eric ;

Sibilia, Jean ;

Pfeffer, Sebastien ;

Wachsmann, Dominique .

PLOS ONE, 2011, 6 (05)

[72] MicroRNA regulation of lymphocyte tolerance and autoimmunity [J].

Simpson, Laura J. ;

Ansel, K. Mark .

JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (06) :2242-2249

[73] Prolonged Tumor Necrosis Factor α Primes Fibroblast-like Synoviocytes in a Gene-Specific Manner by Altering Chromatin [J].

Sohn, Christopher ;

Lee, Angela ;

Qiao, Yu ;

Loupasakis, Konstantinos ;

Ivashkiv, Lionel B. ;

Kalliolias, George D. .

ARTHRITIS & RHEUMATOLOGY, 2015, 67 (01) :86-95

[74] Associations of Smoking and Age With Inflammatory Joint Signs Among Unaffected First-Degree Relatives of Rheumatoid Arthritis Patients [J].

Sparks, Jeffrey A. ;

Chang, Shun-Chiao ;

Deane, Kevin D. ;

Gan, Ryan W. ;

Demoruelle, M. Kristen ;

Feser, Marie L. ;

Moss, LauraKay ;

Buckner, Jane H. ;

Keating, Richard M. ;

Costenbader, Karen H. ;

Gregersen, Peter K. ;

Weisman, Michael H. ;

Mikuls, Ted R. ;

O'Dell, James R. ;

Holers, V. Michael ;

Norris, Jill M. ;

Karlson, Elizabeth W. .

ARTHRITIS & RHEUMATOLOGY, 2016, 68 (08) :1828-1838

[75] Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci [J].

Stahl, Eli A. ;

Raychaudhuri, Soumya ;

Remmers, Elaine F. ;

Xie, Gang ;

Eyre, Stephen ;

Thomson, Brian P. ;

Li, Yonghong ;

Kurreeman, Fina A. S. ;

Zhernakova, Alexandra ;

Hinks, Anne ;

Guiducci, Candace ;

Chen, Robert ;

Alfredsson, Lars ;

Amos, Christopher I. ;

Ardlie, Kristin G. ;

Barton, Anne ;

Bowes, John ;

Brouwer, Elisabeth ;

Burtt, Noel P. ;

Catanese, Joseph J. ;

Coblyn, Jonathan ;

Coenen, Marieke J. H. ;

Costenbader, Karen H. ;

Criswell, Lindsey A. ;

Crusius, J. Bart A. ;

Cui, Jing ;

de Bakker, Paul I. W. ;

De Jager, Philip L. ;

Ding, Bo ;

Emery, Paul ;

Flynn, Edward ;

Harrison, Pille ;

Hocking, Lynne J. ;

Huizinga, Tom W. J. ;

Kastner, Daniel L. ;

Ke, Xiayi ;

Lee, Annette T. ;

Liu, Xiangdong ;

Martin, Paul ;

Morgan, Ann W. ;

Padyukov, Leonid ;

Posthumus, Marcel D. ;

Radstake, Timothy R. D. J. ;

Reid, David M. ;

Seielstad, Mark ;

Seldin, Michael F. ;

Shadick, Nancy A. ;

Steer, Sophia ;

Tak, Paul P. ;

Thomson, Wendy .

NATURE GENETICS, 2010, 42 (06) :508-U56

[76] Altered expression of microRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis [J].

Stanczyk, Joanna ;

Pedrioli, Deena A. Leslie ;

Brentano, Fabia ;

Sanchez-Pernaute, Olga ;

Kolling, Christoph ;

Gay, Renate E. ;

Detmar, Michael ;

Gay, Steffen ;

Kyburz, Diego .

ARTHRITIS AND RHEUMATISM, 2008, 58 (04) :1001-1009

[77] Altered Expression of MicroRNA-203 in Rheumatoid Arthritis Synovial Fibroblasts and Its Role in Fibroblast Activation [J].

Stanczyk, Joanna ;

Ospelt, Caroline ;

Karouzakis, Emmanuel ;

Filer, Andrew ;

Raza, Karim ;

Kolling, Christoph ;

Gay, Renate ;

Buckley, Christopher D. ;

Tak, Paul P. ;

Gay, Steffen ;

Kyburz, Diego .

ARTHRITIS AND RHEUMATISM, 2011, 63 (02) :373-381

[78] Protein Tyrosine Phosphatase Expression Profile of Rheumatoid Arthritis Fibroblast-like Synoviocytes: A Novel Role of SH2 DomainContaining Phosphatase 2 as a Modulator of Invasion and Survival [J].

Stanford, Stephanie M. ;

Maestre, Michael F. ;

Campbell, Amanda M. ;

Bartok, Beatrix ;

Kiosses, William B. ;

Boyle, David L. ;

Arnett, Heather A. ;

Mustelin, Tomas ;

Firestein, Gary S. ;

Bottini, Nunzio .

ARTHRITIS AND RHEUMATISM, 2013, 65 (05) :1171-1180

[79] DNA methyltransferases: a novel target for prevention and therapy [J].

Subramaniam, Dharmalingam ;

Thombre, Ravi ;

Dhar, Animesh ;

Anant, Shrikant .

FRONTIERS IN ONCOLOGY, 2014, 4

[80] On the Origin of Rheumatoid Arthritis: The Impact of Environment and Genes-A Population Based Twin Study [J].

Svendsen, Anders J. ;

Kyvik, Kirsten O. ;

Houen, Gunnar ;

Junker, Peter ;

Christensen, Kaare ;

Christiansen, Lene ;

Nielsen, Christian ;

Skytthe, Axel ;

Hjelmborg, Jacob V. .

PLOS ONE, 2013, 8 (02)

← 1 2 3 4 5 6 7 8 9 10 →