Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes

被引：68

作者：

Doody, Karen M. ^{[1
]}

Bottini, Nunzio ^{[2
]}

Firestein, Gary S. ^{[2
]}

机构：

[1] Mem Univ Newfoundland, Grenfell Campus, Corner Brook, NF, Canada

[2] Univ Calif San Diego, Sch Med, Div Rheumatol Allergy & Immunol, La Jolla, CA 92093 USA

来源：

EPIGENOMICS | 2017年 / 9卷 / 04期

关键词：

epigenetics; fibroblast-like synoviocytes; histone; methylation; microRNA; rheumatoid arthritis; HISTONE DEACETYLASE INHIBITORS; DNA METHYLOME SIGNATURE; SYNOVIAL FIBROBLASTS; ALTERED EXPRESSION; TRICHOSTATIN-A; KEY REGULATOR; MOUSE MODEL; METHYLATION; MICRORNA; RISK;

D O I：

10.2217/epi-2016-0151

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Rheumatoid arthritis is an immune-mediated disease that primarily affects diarthrodial joints. Susceptibility and severity of this disease are influenced by nongenetic factors, such as environmental stress, suggesting an important role of epigenetic changes. In this review, we summarize the epigenetic changes (DNA methylation, histone modification and miRNA expression) in fibroblast-like synoviocytes, which are the joint-lining mesenchymal cells that play an important role in joint inflammation and damage. We also review the effects of these epigenetic changes on rheumatoid arthritis pathogenesis and discuss their therapeutic potential.

引用

页码：479 / 492

页数：14

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