Properly dividing with YAP

被引：3

作者：

Pfeifer, Gerd P. ^{[1
]}

机构：

[1] Van Andel Res Inst, Ctr Epigenet, Grand Rapids, MI 49503 USA

来源：

SCIENCE SIGNALING | 2016年 / 9卷 / 417期

关键词：

HIPPO PATHWAY; ACTIVATION; PROTEIN;

D O I：

10.1126/scisignal.aaf2527

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Hippo pathway prevents organ overgrowth and maintains tissue architecture by inhibiting the transcriptional coactivator YAP. In this issue of Science Signaling, Bui et al. find a role for YAP during cytokinesis that is independent of its transcriptional activity. This function of YAP may be important for maintaining genomic stability in dividing cells.

引用

页数：2

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