Shedding light on the intricate puzzle of ghrelin's effects on appetite regulation

被引：36

作者：

Kola, Blerina ^{[1
]}

Korbonits, Marta ^{[1
]}

机构：

[1] Queen Mary Univ London, Ctr Endocrinol, Barts & London Sch Med & Dent, William Harvey Res Inst, London EC1M 6BQ, England

来源：

JOURNAL OF ENDOCRINOLOGY | 2009年 / 202卷 / 02期

基金：

英国惠康基金;

关键词：

ACTIVATED PROTEIN-KINASE; HORMONE SECRETAGOGUE-RECEPTOR; ACID SYNTHASE INHIBITOR; FOOD-INTAKE; GROWTH-HORMONE; GENE-EXPRESSION; ENERGY; BRAIN; GLUCOSE; AMPK;

D O I：

10.1677/JOE-09-0056

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ghrelin, a hormone primarily produced by the stomach, has a wide range of metabolic and non-metabolic effects. It also stimulates food intake through activation of various hypothalamic and brain stem neurons. A series of recent studies have explored the intracellular mechanisms of the appetite-inducing effect of ghrelin in the hypothalamus, shedding light on the intricate mechanisms of appetite regulation. AMP-activated protein kinase (AMPK) is a key metabolic enzyme involved in appetite regulation. Calmodulin kinase kinase 2 (CaMKK2) has been identified as an upstream kinase of AMPK and a key mediator in the effect of ghrelin on AMPK activity. The fatty acid pathway, hypothalamic mitochondrial respiration, and uncoupling protein 2 have been outlined as downstream tat-gets of AMPK and mediators of ghrelin's appetite stimulating effect. This short overview summarises the present data in this field. Journal of Endocrinology (2009) 202, 191-198

引用

页码：191 / 198

页数：8

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