Epstein-Barr virus as a prognostic factor in de novo nodal diffuse large B-cell lymphoma

被引：42

作者：

Morales, Domingo ^{[4
]}

Beltran, Brady ^{[3
]}

De Mendoza, Fernando Hurtado ^{[3
]}

Riva, Luis ^{[3
]}

Yabar, Alejandro ^{[3
]}

Quinones, Pilar ^{[4
]}

Butera, James N. ^{[2
]}

Castillo, Jorge ^{[1
]}

机构：

[1] Brown Univ, Miriam Hosp, Warren Alpert Med Sch, Div Hematol & Oncol, Providence, RI 02906 USA

[2] Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Div Hematol & Oncol, Providence, RI 02906 USA

[3] Edgardo Rebagliati Martins Hosp, Dept Radiotherapy & Oncol, Lima, Peru

[4] Edgardo Rebagliati Martins Hosp, Dept Pathol, Lima, Peru

来源：

LEUKEMIA & LYMPHOMA | 2010年 / 51卷 / 01期

关键词：

Diffuse large B-cell lymphoma; EBV; prognostic factors; CHOP; NON-HODGKINS-LYMPHOMA; T-CELL; LYMPHOPROLIFERATIVE DISORDERS; DISEASE; CLASSIFICATION; POPULATION; SURVIVAL; RISK; CHEMOTHERAPY; MALIGNANCIES;

D O I：

10.3109/10428190903308015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although the International Prognostic Index (IPI) score is a valuable prognostic tool in diffuse large B-cell lymphoma (DLBCL), other risk-stratifying factors may be of value. The aim of this study was to define the prognostic value of EBV expression in de novo nodal DLBCL. Seventy-four cases were selected between January 2002 and December 2007. Clinical data were reviewed and tissue samples were evaluated for expression of CD20, CD10, bcl-6, MUM1, and EBV-encoded RNA (EBER). Of 74 evaluated cases, 53 cases (72%) were of non-germinal center-like subtype and 11 cases (15%) were positive for EBER. In a univariate analysis of the 57 patients who received chemotherapy, factors associated with survival were EBV status, performance status, LDH level, and IPI score. Using a multivariate analysis, a prognostic model was developed using IPI score and E13V status, which showed statistical significance. Our study supports EBV status as a powerful prognostic factor in de novo nodal DLBCL. Prospective studies should be carried to validate this hypothesis.

引用

页码：66 / 72

页数：7

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