Host/microbiota interactions in health and diseases-Time for mucosal microbiology!

被引:82
作者
Daniel, Noemie [1 ]
Lecuyer, Emelyne [2 ]
Chassaing, Benoit [1 ]
机构
[1] Univ Paris, INSERM U1016, Team Mucosal Microbiota Chron Inflammatory Dis, CNRS UMR 8104, Paris, France
[2] Pasteur Inst, Microenvironm & Immun Unit, INSERM U1224, Paris, France
基金
欧洲研究理事会;
关键词
SEGMENTED FILAMENTOUS BACTERIA; INFLAMMATORY-BOWEL-DISEASE; INVASIVE ESCHERICHIA-COLI; GUT MICROBIOTA; INTESTINAL MICROBIOTA; AKKERMANSIA-MUCINIPHILA; ENERGY-METABOLISM; GENE-EXPRESSION; HIGH PREVALENCE; DIETARY FIBER;
D O I
10.1038/s41385-021-00383-w
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
During the last 20 years, a new field of research delineating the importance of the microbiota in health and diseases has emerged. Inappropriate host-microbiota interactions have been shown to trigger a wide range of chronic inflammatory diseases, and defining the exact mechanisms behind perturbations of such relationship, as well as ways by which these disturbances can lead to disease states, both remain to be fully elucidated. The mucosa-associated microbiota constitutes a recently studied microbial population closely linked with the promotion of chronic intestinal inflammation and associated disease states. This review will highlight seminal works that have brought into light the importance of the mucosa-associated microbiota in health and diseases, emphasizing the challenges and promises of expending the mucosal microbiology field of research.
引用
收藏
页码:1006 / 1016
页数:11
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