Ras superfamily monomeric G proteins in carcinoma cell motility

被引：79

作者：

Oxford, G ^{[1
]}

Theodorescu, D ^{[1
]}

机构：

[1] Univ Virginia, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA

来源：

CANCER LETTERS | 2003年 / 189卷 / 02期

关键词：

Ras; Rho; Rac; Cdc42; Ral; epithelial cells; fibroblasts; tumorigenesis; cell migration; basement membrane;

D O I：

10.1016/S0304-3835(02)00510-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

With over 100 members in humans, the Ras superfamily is a diverse group of monomeric G proteins participating in many cellular processes. Members of the Ras, Rho, and Arf families have been shown to regulate cell motility in fibroblasts and epithelial cells. Ras and Rho family members are also widely involved in human tumorigenesis, either through activating mutations or by overexpression. In this review, tools for studying carcinoma cell migration are discussed and evidence for regulation of carcinoma cell motility by specific Ras superfamily members is summarized. Novel emerging mechanisms of migration in carcinoma cells involving RhoC and Ral are also discussed. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：117 / 128

页数：12

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