A post-insertion strategy for surface functionalization of bacterial and mammalian cell-derived extracellular vesicles

被引：17

作者：

Jiang, Linglei ^{[1
,2
]}

Luirink, Joen ^{[3
,4
]}

Kooijmans, Sander A. A. ^{[1
,2
]}

van Kessel, Kok P. M. ^{[5
]}

Jong, Wouter ^{[4
]}

van Essen, Max ^{[1
,2
]}

Seinen, Cor W. ^{[1
,2
]}

de Maat, Steven ^{[1
,2
]}

de Jong, Olivier G. ^{[1
,2
]}

Gitz-Francois, Jerney F. F. ^{[1
,2
]}

Hennink, Wim E. ^{[6
]}

Vader, Pieter ^{[1
,2
,7
]}

Schiffelers, Raymond M. ^{[1
,2
]}

机构：

[1] UMC Utrecht, Div Lab, CDL Res, Utrecht, Netherlands

[2] Univ Utrecht, Netherlands Fac Med, Utrecht, Netherlands

[3] Vrije Univ, Amsterdam Inst Mol Med & Syst AIMMS, Dept Mol Microbiol, Amsterdam, Netherlands

[4] Abera Biosci AB, Solna, Sweden

[5] UMC Utrecht, Med Microbiol, Utrecht, Netherlands

[6] Univ Utrecht, Fac Sci, Utrecht Inst Pharmaceut Sci, Pharmaceut, Utrecht, Netherlands

[7] UMC Utrecht, Lab Expt Cardiol, Utrecht, Netherlands

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2021年 / 1865卷 / 04期

关键词：

Extracellular vesicles; Outer membrane vesicles; Post-insertion; Poly(ethylene glycol)lipids;

D O I：

10.1016/j.bbagen.2020.129763

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Extracellular vesicles (EVs) are nanoparticles which are released by cells from all three domains of life: Archaea, Bacteria and Eukarya. They can mediate cell-cell communication by transferring cargoes such as proteins and nucleic acids between cells. EVs receive great interest in both academia and industry as they have the potential to be natural drug carriers or vaccine candidates. However, limitations to their clinical translation exist as efficient isolation, loading, labelling and surface-engineering methods are lacking. In this article, we investigate a 'post-insertion' approach, which is commonly used in the functionalization of liposomes in the pharmaceutical field, on two different EV types: mammalian cell-derived EVs and bacteria-derived EVs. We aimed to find an easy and flexible approach to functionalize EVs, thereby improving the labelling, isolation, and surface-engineering.

引用

页数：9

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