Th17 immune response in inflammatory bowel disease: Future roles and opportunities for lactic acid bacteria and bioactive compounds released in fermented milk

被引:10
作者
Santiago-Lopez, Lourdes [1 ]
Hernandez-Mendoza, Adrian [1 ]
Vallejo-Cordoba, Belinda [1 ]
Wall-Medrano, Abraham [2 ]
Gonzalez-Cordova, Aaron F. [1 ]
机构
[1] Ctr Invest Alimentac & Desarrollo AC, Lab Quim & Biotecnol Prod Lacteos, Carretera Gustavo Enrique Astiazaran Rosas, Hermosillo 83304, Sonora, Mexico
[2] Univ Autonoma Ciudad Juarez, Dept Ciencias Quimicobiol, Inst Ciencias Biomed, Anillo Envolvente PRONAF & Estocolmo S-N, Ciudad Juarez 32310, Chihuahua, Mexico
关键词
Lactic acid bacteria; Bioactive compounds; Immune system; Th17; cells; Inflammation; INDUCED COLITIS; T-CELLS; HYPERTENSIVE PATIENTS; LACTOBACILLUS-CASEI; GUT MICROBIOTA; MURINE MODEL; RECEPTOR; IL-17; ACTIVATION; PROBIOTICS;
D O I
10.1016/j.tifs.2021.03.051
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Background: Evidence have shown that Th1-and Th17-related cytokines are often elevated in inflammatory bowel diseases (IBD). Hence, targeting Th17 cells or their effector cytokines represents an attractive alternative for treatment IBD. In this context, recent evidence have indicated that fermented dairy products, with specific lactic acid bacteria, selectively targeting the Th17 lineage, suggesting their effectiveness in preventing and treating IBD. Scope and approach: This review aims to present an overview of the available information on the role of Th17 in inflammatory bowel diseases, and on the potential of fermented milk in the prevention and management of IBD, by modulating this response. Key findings and conclusions: Recent evidence has shown that fermented milks may contain specific bacteria and/ or bioactive compounds (e.g., peptides, exopolysaccharide, free amino acids, organic acid and vitamins) released during fermentation, capable to downregulate the production of pro-inflammatory cytokines related to Th17 cells, including IL-17, IL-10, IFN, IL-6, IL-23, and TGF-beta, by modulating TLR signaling and differentiation of native Th cells into Th1, Th2 or Th17 effector cells. Hence, such fermented milks represent a promising alternative for the treatment of IBD. However, further studies are required to elucidate the molecular mechanisms of bacteria and bioactive components responsible of such anti-inflammatory effects.
引用
收藏
页码:109 / 117
页数:9
相关论文
共 115 条
  • [1] Attenuated GABAergic Signaling in Intestinal Epithelium Contributes to Pathogenesis of Ulcerative Colitis
    Aggarwal, Surbhi
    Ahuja, Vineet
    Paul, Jaishree
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2017, 62 (10) : 2768 - 2779
  • [2] Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells
    Ahern, Philip P.
    Schiering, Chris
    Buonocore, Sofia
    McGeachy, Mandy J.
    Cua, Dan J.
    Maloy, Kevin J.
    Powrie, Fiona
    [J]. IMMUNITY, 2010, 33 (02) : 279 - 288
  • [3] Chemical profiling of Streptomyces sp. Al-Dhabi-2 recovered from an extreme environment in Saudi Arabia as a novel drug source for medical and industrial applications
    Al-Dhabi, Naif Abdullah
    Esmail, Galal Ali
    Duraipandiyan, Veeramuthu
    Arasu, Mariadhas Valan
    [J]. SAUDI JOURNAL OF BIOLOGICAL SCIENCES, 2019, 26 (04) : 758 - 766
  • [4] Isolation, identification and screening of antimicrobial thermophilic Streptomyces sp Al-Dhabi-1 isolated from Tharban hot spring, Saudi Arabia
    Al-Dhabi, Naif Abdullah
    Esmail, Galal Ali
    Duraipandiyan, Veeramuthu
    Arasu, Mariadhas Valan
    Salem-Bekhit, Mounir M.
    [J]. EXTREMOPHILES, 2016, 20 (01) : 79 - 90
  • [5] Exopolysaccharide production by a new Lactobacillus lactis isolated from the fermented milk and its antioxidant properties
    Almalki, Mohammed A.
    [J]. JOURNAL OF KING SAUD UNIVERSITY SCIENCE, 2020, 32 (02) : 1272 - 1277
  • [6] Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients
    Alvarez-Sanchez, Nuria
    Cruz-Chamorro, Ivan
    Diaz-Sanchez, Maria
    Judith Lardone, Patricia
    Miguel Guerrero, Juan
    Carrillo-Vico, Antonio
    [J]. SCIENTIFIC REPORTS, 2019, 9 (1)
  • [7] Antioxidant activity and fatty acid profile of fermented milk prepared by Pediococcus pentosaceus
    Balakrishnan, Gayathri
    Agrawal, Renu
    [J]. JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE, 2014, 51 (12): : 4138 - 4142
  • [8] Invited review: Fermented milk as antihypertensive functional food
    Beltran-Barrientos, L. M.
    Hernandez-Mendoza, A.
    Torres-Llanez, M. J.
    Gonzalez-Cordova, A. F.
    Vallejo-Cordoba, B.
    [J]. JOURNAL OF DAIRY SCIENCE, 2016, 99 (06) : 4099 - 4110
  • [9] GABA, a natural immunomodulator of T lymphocytes
    Bjurstrom, Helen
    Wang, JunYang
    Ericsson, Ida
    Bengtsson, Martin
    Liu, Yawei
    Kurnar-Mendu, Suresh
    Issazadeh-Navikas, Shohreh
    Birnir, Bryndis
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2008, 205 (1-2) : 44 - 50
  • [10] Regulation of inflammation by microbiota interactions with the host
    Blander, J. Magarian
    Longman, Randy S.
    Iliev, Iliyan D.
    Sonnenberg, Gregory F.
    Artis, David
    [J]. NATURE IMMUNOLOGY, 2017, 18 (08) : 851 - 860