Genetics of multiple sclerosis

被引：121
作者：
Dyment, DA
Sadnovich, AD
Ebers, GC
机构：
[1] UNIV WESTERN ONTARIO, DEPT BIOCHEM, LONDON, ENGLAND
[2] UNIV WESTERN ONTARIO, DEPT CLIN NEUROL SCI, LONDON, ENGLAND
[3] UNIV BRITISH COLUMBIA, DEPT MED GENET, VANCOUVER, BC, CANADA
来源：
HUMAN MOLECULAR GENETICS | 1997年 / 6卷 / 10期
关键词：
D O I：
10.1093/hmg/6.10.1693
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Multiple Sclerosis (MS) is a common chronic central nervous system disease in young adults. Relative familial risk appears to be determined largely by genes while population risk is strongly influenced by environmental factors. This is supported by genetic epidemiological studies which also suggest an oligogenic inheritance of susceptibility The HLA DRB1(*)1501, DQA1(*)0102, DQB1 0602 haplotype is associated with the disease but HLA contributes only modestly to overall susceptibility. The results of three genomic searches are concordant with the genetic epidemiology and imply a number of genes with interacting effects will be found. Importantly, no single region has been identified with a major influence on familial risk.
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收藏
页码：1693 / 1698
页数：6
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