Strategies and settings of clinical pharmacogenetic implementation: a scoping review of pharmacogenetics programs

被引:21
作者
Luczak, Tiana [1 ,2 ]
Brown, Sarah Jane [3 ]
Armbruster, Danielle [1 ]
Hundertmark, Megan [1 ]
Brown, Jacob [1 ]
Stenehjem, David [1 ]
机构
[1] Univ Minnesota, Coll Pharm, Dept Pharm Practice & Pharmaceut Sci, Duluth, MN 55812 USA
[2] Essentia Hlth, Duluth, MN 55805 USA
[3] Univ Minnesota, Hlth Sci Lib, Minneapolis, MN 55455 USA
关键词
clinical programs; implementation; pharmacogenetics; scoping review; UNIVERSITY-OF-FLORIDA; PERSONALIZED MEDICINE; DECISION-SUPPORT; HEALTH-CARE; INSTITUTIONAL PROFILE; PRECISION MEDICINE; SYSTEM; BARRIERS; NETWORK; DESIGN;
D O I
10.2217/pgs-2020-0181
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Pharmacogenetic (PGx) literature has shown beneficial outcomes in safety, efficacy and cost when evidence-based gene-drug decision making is incorporated into clinical practice. PGx programs with successfully implemented clinical services have been published in a variety of settings including academic health centers and community practice. The primary objective was to systematically scope the literature to characterize the current trends, extent, range and nature of clinical PGx programs. Forty articles representing 19 clinical PGx programs were included in analysis. Most programs are in urban, academic institutions. Education, governance and workflow were commonly described while billing/reimbursement and consent were not. This review provides an overview of current PGx models that can be used as a reference for institutions beginning the implementation process.
引用
收藏
页码:345 / 364
页数:20
相关论文
共 72 条
[1]   Clinical implementation of pharmacogenomics via a health system-wide research biobank: the University of Colorado experience [J].
Aquilante, Christina L. ;
Kao, David P. ;
Trinkley, Katy E. ;
Lin, Chen-Tan ;
Crooks, Kristy R. ;
Hearst, Emily C. ;
Hess, Steven J. ;
Kudron, Elizabeth L. ;
Lee, Yee Ming ;
Liko, Ina ;
Lowery, Jan ;
Mathias, Rasika A. ;
Monte, Andrew A. ;
Rafaels, Nicholas ;
Rioth, Matthew J. ;
Roberts, Emily R. ;
Taylor, Matthew R. G. ;
Williamson, Connie ;
Barnes, Kathleen C. .
PHARMACOGENOMICS, 2020, 21 (06) :375-386
[2]  
Arksey H., 2005, International Journal of Social Research Methodology, V8, P19, DOI [10.1080/1364557032000119616, DOI 10.1080/1364557032000119616]
[3]   Design and Early Implementation Successes and Challenges of a Pharmacogenetics Consult Clinic [J].
Arwood, Meghan J. ;
Dietrich, Eric A. ;
Duong, Benjamin Q. ;
Smith, D. Max ;
Cook, Kelsey ;
Elchynski, Amanda ;
Rosenberg, Eric, I ;
Huber, Katherine N. ;
Nagoshi, Ying L. ;
Wright, Ashleigh ;
Budd, Jeffrey T. ;
Holland, Neal P. ;
Maska, Edlira ;
Panna, Danielle ;
Elsey, Amanda R. ;
Cavallari, Larisa H. ;
Wiisanen, Kristin ;
Johnson, Julie A. ;
Gums, John G. .
JOURNAL OF CLINICAL MEDICINE, 2020, 9 (07) :1-18
[4]   Implementation of a pharmacist-led pharmacogenomics service for the Program of All-Inclusive Care for the Elderly (PHARM-GENOME-PACE) [J].
Bain, Kevin T. ;
Schwartz, Emily J. ;
Knowlton, Orsula V. ;
Knowlton, Calvin H. ;
Turgeon, Jacques .
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION, 2018, 58 (03) :281-+
[5]   A pilot study of the implementation of pharmacogenomic pharmacist initiated pre-emptive testing in primary care [J].
Bank, Paul C. D. ;
Swen, Jesse J. ;
Schaap, Rowena D. ;
Klootwijk, Danielle B. ;
Baak-Pablo, Renee ;
Guchelaar, Henk-Jan .
EUROPEAN JOURNAL OF HUMAN GENETICS, 2019, 27 (10) :1532-1541
[6]   Development and use of active clinical decision support for preemptive pharmacogenomics [J].
Bell, Gillian C. ;
Crews, Kristine R. ;
Wilkinson, Mark R. ;
Haidar, Cyrine E. ;
Hicks, J. Kevin ;
Baker, Donald K. ;
Kornegay, Nancy M. ;
Yang, Wenjian ;
Cross, Shane J. ;
Howard, Scott C. ;
Freimuth, Robert R. ;
Evans, William E. ;
Broeckel, Ulrich ;
Relling, Mary V. ;
Hoffman, James M. .
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION, 2014, 21 (E1) :E93-E99
[7]   Implementing pharmacogenomics decision support across seven European countries: The Ubiquitous Pharmacogenomics (U-PGx) project [J].
Blagec, Kathrin ;
Koopmann, Rudolf ;
Crommentuijn-van Rhenen, Mandy ;
Holsappel, Inge ;
van der Wouden, Cathelijne H. ;
Konta, Lidija ;
Xu, Hong ;
Steinberger, Daniela ;
Just, Enrico ;
Swen, Jesse J. ;
Guchelaar, Henk-Jan ;
Samwald, Matthias .
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION, 2018, 25 (07) :893-898
[8]   Assessment of provider-perceived barriers to clinical use of pharmacogenomics during participation in an institutional implementation study [J].
Borden, Brittany A. ;
Galecki, Paige ;
Wellmann, Rebecca ;
Danahey, Keith ;
Lee, Sang Mee ;
Patrick-Miller, Linda ;
Sorrentino, Matthew J. ;
Nanda, Rita ;
Koyner, Jay L. ;
Polonsky, Tamar S. ;
Stadler, Walter M. ;
Mulcahy, Cathleen ;
Kavitt, Robert T. ;
Ratain, Mark J. ;
Meltzer, David O. ;
O'Donnell, Peter H. .
PHARMACOGENETICS AND GENOMICS, 2019, 29 (02) :31-38
[9]   Clinical Implementation of Pharmacogenetic Testing in a Hospital of the Spanish National Health System: Strategy and Experience Over 3 Years [J].
Borobia, Alberto M. ;
Dapia, Irene ;
Tong, Hoi Y. ;
Arias, Pedro ;
Munoz, Mario ;
Tenorio, Jair ;
Hernandez, Rafael ;
Garcia Garcia, Irene ;
Gordo, Gema ;
Ramirez, Elena ;
Frias, Jesus ;
Lapunzina, Pablo ;
Carcas, Antonio J. .
CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2018, 11 (02) :189-199
[10]   Genotype, phenotype, and medication recommendation agreement among commercial pharmacogenetic-based decision support tools [J].
Bousman, Chad A. ;
Dunlop, Boadie W. .
PHARMACOGENOMICS JOURNAL, 2018, 18 (05) :613-622