Co-encapsulation of curcumin and tamoxifen in lipid-chitosan hybrid nanoparticles for cancer therapy

被引：38

作者：

Alhajamee, Maitham ^{[1
]}

Marai, Khadeeja ^{[1
]}

Al Abbas, Sameer Mohammed Naser ^{[1
]}

Tabrizi, Masoud Homayouni ^{[1
]}

机构：

[1] Islamic Azad Univ, Dept Biol, Mashhad Branch, Mashhad, Razavi Khorasan, Iran

来源：

MATERIALS TECHNOLOGY | 2022年 / 37卷 / 09期

关键词：

encapsulation; Lipid-Chitosan Hybrid Nanoparticles; curcumin; cancer therapy; IN-VITRO; LECITHIN/CHITOSAN NANOPARTICLES; ANTICANCER ACTIVITY; CONTROLLED-RELEASE; ESTROGEN-RECEPTOR; DELIVERY; COMBINATION; EXPRESSION; PACLITAXEL; APOPTOSIS;

D O I：

10.1080/10667857.2021.1926811

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Background: Lipid-polymer hybrid nanoparticles (LPHNP) are used for drug delivery due to their high advantages over polymeric or lipid nanoparticles. Materials and methods: Tamoxifen-Curcumin-loaded-LPHNPs (Tmx-Cu-LPHNPs) were synthetized by the ionic gelation method, and after characterization and calculation of the encapsulation efficiency, its antioxidant power, anti-cancer and anti-metastatic effects were examined. Results: Tmx-Cu-LPHNPswith size of 232.12 nm, PDI: 0.22, zeta-p: 35.12 mV and encapsulation efficiencies92% and 74% for Cu and Tmx (respectively) inhibited cancer cells more strongly than normal cells.In addition, Tmx-Cu-LPHNPsinhibited ABTS (IC50: 998.125 mu g/ml), DPPH (IC50:164.87 mu g/ml) free radicals as well as reducing iron ions.Up regulation of P53 and Caspase-9, flow cytometry and AO/PI staining demonstrated proapoptotic effects of Tmx-Cu-LPHNPs. Suppression of metastasis in cancer cells confirmed by scratch assay and decreased expression of metalloproteinase (MMP-2, 9) genes. Conclusion: Tmx-Cu-LPHNPs can be a promising factor in the treatment of cancer with appropriate therapeutic effects.

引用

页码：1183 / 1194

页数：12

共 61 条

[51] In vitro cytotoxic efficacy of PEG encapsulated manganese-doped zinc oxide nanoparticles on hepatocellular carcinoma cells [J].

Vijayakumar, G. ;

Boopathi, G. ;

Elango, M. .

MATERIALS TECHNOLOGY, 2019, 34 (13) :807-817

[52] Cytotoxic effects of curcumin on osteosarcoma cell lines [J].

Walters, Denise K. ;

Muff, Roman ;

Langsam, Bettina ;

Born, Walter ;

Fuchs, Bruno .

INVESTIGATIONAL NEW DRUGS, 2008, 26 (04) :289-297

[53] Chitosan-based injectable hydrogels for biomedical applications [J].

Wang, K. ;

Buschle-Diller, G. ;

Misra, R. D. K. .

MATERIALS TECHNOLOGY, 2015, 30 (B4) :B198-B205

[54] Synergistic antitumor effect of curcumin and dinitrosyl iron complexes for against melanoma cells [J].

Wen, Yu-Der ;

Ho, Yun-Lung ;

Shiau, Rong-Jen ;

Yeh, Jung-Kai ;

Wu, Jheng-Yu ;

Wang, Wei-Lung ;

Chiou, Show-Jen .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2010, 695 (03) :352-359

[55] Ovarian Cancer Risk Factors by Histologic Subtype: An Analysis From the Ovarian Cancer Cohort Consortium [J].

Wentzensen, Nicolas ;

Poole, Elizabeth M. ;

Trabert, Britton ;

White, Emily ;

Arslan, Alan A. ;

Patel, Alpa V. ;

Setiawan, V. Wendy ;

Visvanathan, Kala ;

Weiderpass, Elisabete ;

Adami, Hans-Olov ;

Black, Amanda ;

Bernstein, Leslie ;

Brinton, Louise A. ;

Buring, Julie ;

Butler, Lesley M. ;

Chamosa, Saioa ;

Clendenen, Tess V. ;

Dossus, Laure ;

Fortner, Renee ;

Gapstur, Susan M. ;

Gaudet, Mia M. ;

Gram, Inger T. ;

Hartge, Patricia ;

Hoffman-Bolton, Judith ;

Idahl, Annika ;

Jones, Michael ;

Kaaks, Rudolf ;

Kirsh, Victoria ;

Koh, Woon-Puay ;

Lacey, James V., Jr. ;

Lee, I-Min ;

Lundin, Eva ;

Merritt, Melissa A. ;

Onland-Moret, N. Charlotte ;

Peters, Ulrike ;

Poynter, Jenny N. ;

Rinaldi, Sabina ;

Robien, Kim ;

Rohan, Thomas ;

Sandler, Dale P. ;

Schairer, Catherine ;

Schouten, Leo J. ;

Sjoholm, Louise K. ;

Sieri, Sabina ;

Swerdlow, Anthony ;

Tjonneland, Anna ;

Travis, Ruth ;

Trichopoulou, Antonia ;

van den Brandt, Piet A. ;

Wilkens, Lynne .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (24) :2888-+

[56] Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth [J].

Yallapu, Murali M. ;

Maher, Diane M. ;

Sundram, Vasudha ;

Bell, Maria C. ;

Jaggi, Meena ;

Chauhan, Subhash C. .

JOURNAL OF OVARIAN RESEARCH, 2010, 3

[57] Formulation and evaluation of controlled-release of steroidal saponins-loaded collagen microspheres [J].

Yang, Chunrong ;

Wu, Huazhong ;

Wang, Jianhua .

MATERIALS TECHNOLOGY, 2019, 34 (09) :534-539

[58] Targeted delivery of 10-hydroxycamptothecin to human breast cancers by cyclic RGD-modified lipid-polymer hybrid nanoparticles [J].

Yang, Zhe ;

Luo, Xingen ;

Zhang, Xiaofang ;

Liu, Jie ;

Jiang, Qing .

BIOMEDICAL MATERIALS, 2013, 8 (02)

[59] Formation of stable nanoparticles via electrostatic complexation between sodium caseinate and gum arabic [J].

Ye, AQ ;

Flanagan, J ;

Singh, H .

BIOPOLYMERS, 2006, 82 (02) :121-133

[60] Anti-inflammatory effects of the extract of Solanum nigrum L. on an acute ear edema mouse model [J].

Yeom, Young-Eun ;

Kim, Min Ah ;

Kim, Jin ;

Lee, Chang-Moon .

MATERIALS TECHNOLOGY, 2019, 34 (14) :851-857

← 1 2 3 4 5 6 7 →