Co-encapsulation of curcumin and tamoxifen in lipid-chitosan hybrid nanoparticles for cancer therapy

被引：38
作者：
Alhajamee, Maitham [1 ]
Marai, Khadeeja [1 ]
Al Abbas, Sameer Mohammed Naser [1 ]
Tabrizi, Masoud Homayouni [1 ]
机构：
[1] Islamic Azad Univ, Dept Biol, Mashhad Branch, Mashhad, Razavi Khorasan, Iran
来源：
MATERIALS TECHNOLOGY | 2022年 / 37卷 / 09期
关键词：
encapsulation; Lipid-Chitosan Hybrid Nanoparticles; curcumin; cancer therapy; IN-VITRO; LECITHIN/CHITOSAN NANOPARTICLES; ANTICANCER ACTIVITY; CONTROLLED-RELEASE; ESTROGEN-RECEPTOR; DELIVERY; COMBINATION; EXPRESSION; PACLITAXEL; APOPTOSIS;
D O I：
10.1080/10667857.2021.1926811
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Background: Lipid-polymer hybrid nanoparticles (LPHNP) are used for drug delivery due to their high advantages over polymeric or lipid nanoparticles. Materials and methods: Tamoxifen-Curcumin-loaded-LPHNPs (Tmx-Cu-LPHNPs) were synthetized by the ionic gelation method, and after characterization and calculation of the encapsulation efficiency, its antioxidant power, anti-cancer and anti-metastatic effects were examined. Results: Tmx-Cu-LPHNPswith size of 232.12 nm, PDI: 0.22, zeta-p: 35.12 mV and encapsulation efficiencies92% and 74% for Cu and Tmx (respectively) inhibited cancer cells more strongly than normal cells.In addition, Tmx-Cu-LPHNPsinhibited ABTS (IC50: 998.125 mu g/ml), DPPH (IC50:164.87 mu g/ml) free radicals as well as reducing iron ions.Up regulation of P53 and Caspase-9, flow cytometry and AO/PI staining demonstrated proapoptotic effects of Tmx-Cu-LPHNPs. Suppression of metastasis in cancer cells confirmed by scratch assay and decreased expression of metalloproteinase (MMP-2, 9) genes. Conclusion: Tmx-Cu-LPHNPs can be a promising factor in the treatment of cancer with appropriate therapeutic effects.
引用
收藏
页码：1183 / 1194
页数：12
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