Co-encapsulation of curcumin and tamoxifen in lipid-chitosan hybrid nanoparticles for cancer therapy

被引：38
作者：
Alhajamee, Maitham [1 ]
Marai, Khadeeja [1 ]
Al Abbas, Sameer Mohammed Naser [1 ]
Tabrizi, Masoud Homayouni [1 ]
机构：
[1] Islamic Azad Univ, Dept Biol, Mashhad Branch, Mashhad, Razavi Khorasan, Iran
来源：
MATERIALS TECHNOLOGY | 2022年 / 37卷 / 09期
关键词：
encapsulation; Lipid-Chitosan Hybrid Nanoparticles; curcumin; cancer therapy; IN-VITRO; LECITHIN/CHITOSAN NANOPARTICLES; ANTICANCER ACTIVITY; CONTROLLED-RELEASE; ESTROGEN-RECEPTOR; DELIVERY; COMBINATION; EXPRESSION; PACLITAXEL; APOPTOSIS;
D O I：
10.1080/10667857.2021.1926811
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Background: Lipid-polymer hybrid nanoparticles (LPHNP) are used for drug delivery due to their high advantages over polymeric or lipid nanoparticles. Materials and methods: Tamoxifen-Curcumin-loaded-LPHNPs (Tmx-Cu-LPHNPs) were synthetized by the ionic gelation method, and after characterization and calculation of the encapsulation efficiency, its antioxidant power, anti-cancer and anti-metastatic effects were examined. Results: Tmx-Cu-LPHNPswith size of 232.12 nm, PDI: 0.22, zeta-p: 35.12 mV and encapsulation efficiencies92% and 74% for Cu and Tmx (respectively) inhibited cancer cells more strongly than normal cells.In addition, Tmx-Cu-LPHNPsinhibited ABTS (IC50: 998.125 mu g/ml), DPPH (IC50:164.87 mu g/ml) free radicals as well as reducing iron ions.Up regulation of P53 and Caspase-9, flow cytometry and AO/PI staining demonstrated proapoptotic effects of Tmx-Cu-LPHNPs. Suppression of metastasis in cancer cells confirmed by scratch assay and decreased expression of metalloproteinase (MMP-2, 9) genes. Conclusion: Tmx-Cu-LPHNPs can be a promising factor in the treatment of cancer with appropriate therapeutic effects.
引用
收藏
页码：1183 / 1194
页数：12
相关论文
共 61 条
[1]   PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect [J].
Acharya, Sarbari ;
Sahoo, Sanjeeb K. .
ADVANCED DRUG DELIVERY REVIEWS, 2011, 63 (03) :170-183
[2]  
Aristotle L, 2004, ANTICANCER RES, V24, P987
[3]   Greener synthesis of cerium oxide nanoemulsion using pollen grains of Brassica napus and evaluation of its antitumour and cytotoxicity properties. [J].
Ashna, Mohammad ;
Es-Haghi, Ali ;
Karimi Noghondar, Maryam ;
Al Amara, Dheyaa ;
Yazdi, Mohammad Ehsan Taghavizadeh .
MATERIALS TECHNOLOGY, 2022, 37 (08) :525-532
[4]   Pomegranate extract-loaded solid lipid nanoparticles: design, optimization, and in vitro cytotoxicity study [J].
Badawi, Noha M. ;
Teaima, Mahmoud H. ;
El-Say, Khalid M. ;
Attia, Dalia A. ;
El-Nabarawi, Mohamed A. ;
Elmazar, Mohey M. E. .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2018, 13 :1313-1326
[5]   Lecithin/chitosan controlled release nanopreparations of tamoxifen citrate: Loading, enzyme-trigger release and cell uptake [J].
Barbieri, Stefano ;
Sonvico, Fabio ;
Como, Caterina ;
Colombo, Gaia ;
Zani, Franca ;
Buttini, Francesca ;
Bettini, Ruggero ;
Rossi, Alessandra ;
Colombo, Paolo .
JOURNAL OF CONTROLLED RELEASE, 2013, 167 (03) :276-283
[6]   Chitosan coated layered clay montmorillonite nanocomposites modulate oral delivery of paclitaxel in colonic cancer [J].
Bothiraja, C. ;
Thorat, U. H. ;
Pawar, A. P. ;
Shaikh, K. S. .
MATERIALS TECHNOLOGY, 2014, 29 (B2) :B120-B126
[7]   Preparation of Curcumin-Loaded Liposomes and Evaluation of Their Skin Permeation and Pharmacodynamics [J].
Chen, Yan ;
Wu, Qingqing ;
Zhang, Zhenghai ;
Yuan, Ling ;
Liu, Xuan ;
Zhou, Lei .
MOLECULES, 2012, 17 (05) :5972-5987
[8]   Developing a Highly Stable PLGA-mPEG Nanoparticle Loaded with Cisplatin for Chemotherapy of Ovarian Cancer [J].
Cheng, Lihua ;
Jin, Chengmeng ;
Lv, Wen ;
Ding, Qiuping ;
Han, Xu .
PLOS ONE, 2011, 6 (09)
[9]   Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems [J].
Danaei, M. ;
Dehghankhold, M. ;
Ataei, S. ;
Davarani, F. Hasanzadeh ;
Javanmard, R. ;
Dokhani, A. ;
Khorasani, S. ;
Mozafari, M. R. .
PHARMACEUTICS, 2018, 10 (02)
[10]  
Deljoo S., 2018, Asian J. Nanosci. Mater, V2, P66, DOI DOI 10.26655/AJNANOMAT.2019.1.5
1234567